Finerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy

Finerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy

Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays. The mineralocorticoid receptor (MR) is a classical ligand-activa...

Full description

Saved in:
Bibliographic Details
Main Authors: Zi-Han Li, Zi-Jun Sun, Sydney C. W. Tang, Ming-Hui Zhao, Min Chen, Dong-Yuan Chang
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
diabetic nephropathy
finerenone
MR
C5aR1
Gn?i2
Online Access:https://www.mdpi.com/2073-4409/14/5/337
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items