On the criteria for the severity of Infectious mononucleosis in hospitalized children
Purpose of the study. Justification of the practical application of laboratory criteria marking the severity of infectious mononucleosis in hospitalized children.Materials and methods. A comparative prospective clinical study involved 54 children, aged 2 to 13 years, median age 5 years [3.0; 8.7]. T...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2020-03-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/480 |
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| author | N. S. Pospelova N. O. Postanogova M. O. Satyukova A. Yu. Deryusheva A. V. Permyakova |
| author_facet | N. S. Pospelova N. O. Postanogova M. O. Satyukova A. Yu. Deryusheva A. V. Permyakova |
| author_sort | N. S. Pospelova |
| collection | DOAJ |
| description | Purpose of the study. Justification of the practical application of laboratory criteria marking the severity of infectious mononucleosis in hospitalized children.Materials and methods. A comparative prospective clinical study involved 54 children, aged 2 to 13 years, median age 5 years [3.0; 8.7]. The main study group consisted of 27 children with a severity of the disease, the comparison group — 27 patients of moderate. We used the Mann-Whitney test, Spearman's correlation coefficient and mathematical modeling.Results. The study found a direct correlative relationship between the severity of infectious mononucleosis and indicators of total and direct bilirubin, r = 0.39. «Cut of» values were determined: for total bilirubin ≥ 15 µmol / L, for direct bilirubin ≥ 5.5 µmol / L, sensitivity 96%, specificity 52%.Conclusions. «Cut of» bilirubin fractions can be used to predict the severity of infectious mononucleosis in hospitalized children on the first day of the disease. |
| format | Article |
| id | doaj-art-bf8a97ea976b4b6fb512916d93f0038c |
| institution | DOAJ |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2020-03-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-bf8a97ea976b4b6fb512916d93f0038c2025-08-20T02:46:33ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072020-03-01191262810.22627/2072-8107-2020-19-1-26-28437On the criteria for the severity of Infectious mononucleosis in hospitalized childrenN. S. Pospelova0N. O. Postanogova1M. O. Satyukova2A. Yu. Deryusheva3A. V. Permyakova4Perm State Medical University named after Academician E.A. Wagner Ministry of Health of RussiaPerm State Medical University named after Academician E.A. Wagner Ministry of Health of RussiaPerm State Medical University named after Academician E.A. Wagner Ministry of Health of RussiaPerm State Medical University named after Academician E.A. Wagner Ministry of Health of RussiaPerm State Medical University named after Academician E.A. Wagner Ministry of Health of RussiaPurpose of the study. Justification of the practical application of laboratory criteria marking the severity of infectious mononucleosis in hospitalized children.Materials and methods. A comparative prospective clinical study involved 54 children, aged 2 to 13 years, median age 5 years [3.0; 8.7]. The main study group consisted of 27 children with a severity of the disease, the comparison group — 27 patients of moderate. We used the Mann-Whitney test, Spearman's correlation coefficient and mathematical modeling.Results. The study found a direct correlative relationship between the severity of infectious mononucleosis and indicators of total and direct bilirubin, r = 0.39. «Cut of» values were determined: for total bilirubin ≥ 15 µmol / L, for direct bilirubin ≥ 5.5 µmol / L, sensitivity 96%, specificity 52%.Conclusions. «Cut of» bilirubin fractions can be used to predict the severity of infectious mononucleosis in hospitalized children on the first day of the disease.https://detinf.elpub.ru/jour/article/view/480infectious mononucleosisepstein-barr viruscytomegaloviruschildrenbilirubin |
| spellingShingle | N. S. Pospelova N. O. Postanogova M. O. Satyukova A. Yu. Deryusheva A. V. Permyakova On the criteria for the severity of Infectious mononucleosis in hospitalized children Детские инфекции (Москва) infectious mononucleosis epstein-barr virus cytomegalovirus children bilirubin |
| title | On the criteria for the severity of Infectious mononucleosis in hospitalized children |
| title_full | On the criteria for the severity of Infectious mononucleosis in hospitalized children |
| title_fullStr | On the criteria for the severity of Infectious mononucleosis in hospitalized children |
| title_full_unstemmed | On the criteria for the severity of Infectious mononucleosis in hospitalized children |
| title_short | On the criteria for the severity of Infectious mononucleosis in hospitalized children |
| title_sort | on the criteria for the severity of infectious mononucleosis in hospitalized children |
| topic | infectious mononucleosis epstein-barr virus cytomegalovirus children bilirubin |
| url | https://detinf.elpub.ru/jour/article/view/480 |
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