Anti-HMGCR myopathy: a first case report from North Africa and literature insights

Anti-HMGCR myopathy: a first case report from North Africa and literature insights

Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy is a rare idiopathic inflammatory myopathy characterized by severe muscle damage and minimal extra-muscular involvement. This report presents the first documented case of severe, treatment-resistant HMGCR-myopathy in a Tunisi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Houssem Abida, Imen Zamali, Imène Rachdi, Zakaria Saied, Ahlem Ben Hmid, Samar Samoud, Yousr Galai, Fatma Daoud, Fatma Boussema, Samia Ben Sassi, Zohra Aydi, Mélika Ben Ahmed
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Immunology
Subjects:	case report autoimmunity anti-HMGCR inflammatory myopathy therapeutics
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590913/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Molecular allergen sensitization profile and casein threshold determination predicting the persistence of cow's milk protein allergy in Tunisia (North Africa)
by: Yasmina Ouerdani, et al.
Published: (2025-04-01)

Prevalence and clinical implications of major and minor ANCAs in Tunisian (North African) patients with systemic lupus erythematosus
by: Zeineb Meddeb, et al.
Published: (2025-08-01)

High Prevalence of aCL-IgA and aβ2GPI-IgA in Drug-Free Schizophrenia Patients: Evidence of a Potential Autoimmune Link
by: Samar Samoud, et al.
Published: (2024-11-01)

Urticarial hypocomplementemic vasculitis syndrome and systemic lupus erythematosus: a case report and review of the literature
by: Yasmina Ouerdani, et al.
Published: (2025-08-01)

Exploring the landscape of symptom-specific inflammatory cytokines in post-COVID syndrome patients
by: Chafik Tilikete, et al.
Published: (2024-11-01)

Autoimmune Encephalitis in Tunisia: Report of a Pediatric Cohort
by: Bissene Douma, et al.
Published: (2021-01-01)

Contribution of lung ultrasound to assess COVID-19 pneumonia in critical care setting: a prospective cohort study
by: Amira Jamoussi, et al.
Published: (2025-07-01)

Bacillus Spizizenii FMH45-based biofertilizer enhances growth and halotolerance of cherry tomato plants under hydroponic cultivation systems
by: Fatma Masmoudi, et al.
Published: (2025-01-01)

Genotypic Differences Affecting Biometric, Processing and Functional Quality Attributes in Tomato Fruits
by: Yors Laayouni, et al.
Published: (2022-08-01)

A comprehensive review of carbon sequestration and its assessment techniques using remote sensing and geospatial methods
by: Imen Ben Salem
Published: (2025-01-01)

A rare presentation of stiff-person syndrome with a nonspecific focal myositis: A case report
by: Arij Ezzouhour Yahyaoui, et al.
Published: (2024-09-01)

Effect of The Storage Period on the Antioxidant Properties of Different Watermelon Cultivars Grown in Tunisia
by: Imen Tlili, et al.
Published: (2022-06-01)

The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial
by: Houssem Marzougui, et al.
Published: (2024-10-01)

Dental Management of a Tunisian Child with Sanjad-Sakati Syndrome
by: Farah Chouchene, et al.
Published: (2022-01-01)

HANLEY Will, Identifying with Nationality: Europeans, Ottomans, and Egyptians in Alexandria
by: Fatma Ben Slimane
Published: (2022-12-01)

Investigation of a Cluster of Candida albicans Invasive Candidiasis in a Neonatal Intensive Care Unit by Pulsed-Field Gel Electrophoresis
by: Jihene Ben Abdeljelil, et al.
Published: (2012-01-01)

The role of chromatin state in intron retention: A case study in leveraging large scale deep learning models.
by: Ahmed Daoud, et al.
Published: (2025-01-01)

Synchronous occurrence of papillary thyroid carcinoma and solitary fibrous tumor of the thyroid: a case report
by: Maissa Ben Thayer, et al.
Published: (2024-12-01)

Consumer reactions to rebranding strategy in emerging markets: evidence from the tunisian retail sector and the “promogro” to “MG maxi” transition
by: Ahmed Kannou, et al.
Published: (2025-12-01)

Acute pancreatitis revealing duodenal papilla MALT lymphoma: a case report and review of the literature
by: Wafa Dahmani, et al.
Published: (2025-12-01)

Assessment of Histopathological Alterations and Oxidative Stress in the Liver and Kidney of Male Rats following Exposure to Aluminum Chloride
by: Anfal Kadhim, et al.
Published: (2024-01-01)

High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of the literature
by: Asma Tajouri, et al.
Published: (2025-08-01)

Isolated Hydatid Cyst of the Breast: A Rare Pseudotumor of the Breast
by: Badra Bannour, et al.
Published: (2025-04-01)

Physicochemical Characterization of Geopolymer Binders and Foams Made from Tunisian Clay
by: Imen Ben Messaoud, et al.
Published: (2018-01-01)

Classification automatique d’emprises au sol de maisons dites « andalouses » à l’aide de modèle de Machine Learning
by: Ben Zid Afef, et al.
Published: (2024-01-01)

IT Governance in the e-Business Era
by: Saida Harguem, et al.
Published: (2022-10-01)

Corrigendum: Unlocking the therapeutic potential of Saussurea costus: purification and functional characterization of α-amylase inhibitors
by: Imen Ben Abdelmalek, et al.
Published: (2025-03-01)

Interventions to improve adherence/compliance to home noninvasive positive pressure ventilation in stable hypercapnic chronic obstructive pulmonary disease patients: A systematic review protocol.
by: Amani Kacem, et al.
Published: (2025-01-01)

Structural, optical and biological characterization of a new cobalt-based mixed halide hybrid compound: insights from DFT and vibrational analysis
by: Iteb Ben Mahmoud, et al.
Published: (2025-07-01)

Contribution of 2 D strain in the detection of subtle myocardial involvement in group A and B patients with chronic obstructive pulmonary disease
by: Rania Kaddoussi, et al.
Published: (2025-06-01)

Influencing factors of health-related quality-of-life perceived by both children/adolescents patients with type-1 diabetes mellitus and their parents: A North-African study [version 1; peer review: 2 approved]
by: Jihene Bouguila, et al.
Published: (2024-04-01)

Dynamics of SARS-CoV-2 antibodies after natural infection: insights from a study on Pasteur Institute of Tunis employees
by: Ines Cherif, et al.
Published: (2024-12-01)

Lymphoblastoid and Jurkat cell lines are useful surrogate in developing a CRISPR-Cas9 method to correct leukocyte adhesion deficiency genomic defect
by: Ahmad R. Ramadan, et al.
Published: (2025-03-01)

Gastric metastasis and peritoneal carcinosis revealing primary breast cancer: an unusual presentation
by: Shema Ayadi, et al.
Published: (2024-12-01)

A Selective Electrochemical Sensor for Bisphenol A Detection Based on Cadmium (II) (bromophenyl)porphyrin and Gold Nanoparticles
by: Fatma Rejab, et al.
Published: (2024-12-01)

Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature
by: Hiba Ben Abdelhafidh, et al.
Published: (2025-01-01)

Comparison of two quantitative real time PCR assays for Rickettsia detection in patients from Tunisia.
by: Abir Znazen, et al.
Published: (2015-02-01)

Teucrium polium L.: Antimicrobial and Antioxidant Properties with an Emphasis on Oxidative Stress and Gastric Ulcer induced by ethanol in albinos rats
by: Rim Ben Mansour, et al.
Published: (2025-04-01)

Osteoid Osteoma of the Basilar Border of the Mandible: A Diagnostic Dilemma
by: Rym Kammoun, et al.
Published: (2022-01-01)

Temporomandibular Joint Ankylosis as a Sequel of an Overlooked Condylar Fracture in a Child
by: Manel Gharbi, et al.
Published: (2024-01-01)