1-Phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide hybrids as new α-glucosidase inhibitors

1-Phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide hybrids as new α-glucosidase inhibitors

Abstract In this work, 1-phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide skeleton as a novel scaffold was designed based on hybridization of moieties that were found in the potent α-glucosidase inhibitors. Fourteen derivatives 14a-n of this scaffold were synthesized by the efficien...

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Bibliographic Details
Main Authors: Elham Safaie, Mohammad Hosein Sayahi, Navid Dastyafteh, Mohammad Halimi, Milad Noori, Maryam Mohammadi-Khanaposhtani, Afsaneh Zonouzi, Roghieh Mirzazadeh, Azadeh Tajmir-Riahi, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Mehdi Asadi, Mohammad Mahdavi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
β-Carboline
1,2,3-Triazole
α-Glucosidase
Online Access:https://doi.org/10.1038/s41598-025-99807-x
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