Analysis of global ovarian cancer disease burden and its changing trend from 1990 to 2021
Abstract Background Research on the burden of disease for ovarian cancer (OC) remains notably limited at present. The objective of this study is to conduct a comprehensive analysis of the Global Burden of Disease (GBD) study, spanning the period from 1990 to 2021, in order to elucidate the incidence...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-025-03904-y |
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| Summary: | Abstract Background Research on the burden of disease for ovarian cancer (OC) remains notably limited at present. The objective of this study is to conduct a comprehensive analysis of the Global Burden of Disease (GBD) study, spanning the period from 1990 to 2021, in order to elucidate the incidence and burden of OC. This will thereby inform targeted policies and strategies related to prevention, screening, and treatment. Methods The incidence and disability-adjusted life years (DALYs) of OC were analyzed based on age group and sociodemographic index (SDI). The estimated annual percentage change (EAPC) was employed to evaluate trends in OC over the period from 1990 to 2021. Results Globally, the incidence of OC has risen significantly from 159,096 cases in 1990 to 298,876 cases in 2021. The corresponding global age-standardised incidence rates (ASIR) of OC demonstrated a significant increase from 1990 to 2021 (EAPC = 0.06), while the global age-standardised DALY rates of OC indicated a decrease (EAPC=-0.38). Central Europe presented with both the highest ASIR and DALY rates (10.8 and 205.22 per 100,000 respectively). At the regional and country level, Andean Latin America exhibited the most rapid increases in ASIR and DALYs (EAPC = 2.12 and 4.90 respectively), with the largest increases being observed in Ecuador (EAPC = 6.64 and 6.39 respectively). These data suggest that the global standardised incidence rate of OC peaks between the ages of 70 and 74. Conclusion Globally, the burden of ASIR due to OC has risen steadily from 1990 to 2021. This increase has been particularly pronounced in countries with low and medium SDI and in individuals aged between 70 and 74 years. The regions that currently bear the brunt of this disease include Central and Eastern Europe, Andean Latin America, and Sub-Saharan Africa. Notably, there is an observable shift in disease burden towards regions with lower socioeconomic status. |
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| ISSN: | 1472-6874 |