Multiplex engineering using microRNA-mediated gene silencing in CAR T cells

Multiplex engineering using microRNA-mediated gene silencing in CAR T cells

BackgroundMultiplex gene-edited chimeric antigen receptor (CAR) T-cell therapies face significant challenges, including potential oncogenic risks associated with double-strand DNA breaks. Targeted microRNAs (miRNAs) may provide a safer, functional, and tunable alternative for gene silencing without...

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Main Authors: Giulia Golinelli, John Scholler, Audrey Roussel-Gervais, Antonija Šakić, Sten Ilmjärv, Decheng Song, Khatuna Gabunia, Mei Ji, Ting J. Fan, Aasha Gupta, Mansi Deshmukh, Abdulla Berjis, Riccardo Cuoghi Costantini, Kimberly Apodaca, Neil C. Sheppard, Sven Kili, Massimo Dominici, Marco Alessandrini, Carl H. June, Bruce L. Levine
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
CAR T
miRNAs
CRISPR/Cas9
multiplexing
solid tumors
gene silencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1647433/full
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