Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus
The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, t...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/9631435 |
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| _version_ | 1832564428776669184 |
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| author | Muhammad U. Sohail Asmaa Althani Haseeb Anwar Roberto Rizzi Hany E. Marei |
| author_facet | Muhammad U. Sohail Asmaa Althani Haseeb Anwar Roberto Rizzi Hany E. Marei |
| author_sort | Muhammad U. Sohail |
| collection | DOAJ |
| description | The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, the disease progression is particularly linked with functional and taxonomic alterations in the gastrointestinal tract microbiome. A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years. |
| format | Article |
| id | doaj-art-bf7060e70f214c0cbfb23d791d0a3ab2 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-bf7060e70f214c0cbfb23d791d0a3ab22025-02-03T01:11:10ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/96314359631435Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes MellitusMuhammad U. Sohail0Asmaa Althani1Haseeb Anwar2Roberto Rizzi3Hany E. Marei4Biomedical Research Center, Qatar University, P.O. Box 2713, Doha, QatarBiomedical Research Center, Qatar University, P.O. Box 2713, Doha, QatarGovernment College University, Faisalabad 38000, PakistanInstitute of Cell Biology and Neurobiology (IBCN), Italian National Council of Research (CNR), Rome, ItalyBiomedical Research Center, Qatar University, P.O. Box 2713, Doha, QatarThe incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, the disease progression is particularly linked with functional and taxonomic alterations in the gastrointestinal tract microbiome. A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years.http://dx.doi.org/10.1155/2017/9631435 |
| spellingShingle | Muhammad U. Sohail Asmaa Althani Haseeb Anwar Roberto Rizzi Hany E. Marei Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus Journal of Diabetes Research |
| title | Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus |
| title_full | Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus |
| title_fullStr | Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus |
| title_full_unstemmed | Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus |
| title_short | Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus |
| title_sort | role of the gastrointestinal tract microbiome in the pathophysiology of diabetes mellitus |
| url | http://dx.doi.org/10.1155/2017/9631435 |
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