Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements
Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. We report a blastoid variant of mantle cell lymphoma (MCL) involving an inguinal lymph node that, in addition to classi...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/8303571 |
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| author | Christopher L. Felten Joel A. Chan Dulce R. DeCastro Jean Lopategui Swapnil P. Rajurkar |
| author_facet | Christopher L. Felten Joel A. Chan Dulce R. DeCastro Jean Lopategui Swapnil P. Rajurkar |
| author_sort | Christopher L. Felten |
| collection | DOAJ |
| description | Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. We report a blastoid variant of mantle cell lymphoma (MCL) involving an inguinal lymph node that, in addition to classical phenotypic and genetic findings, also aberrantly coexpresses surface CD10 and cytoplasmic CD3. Small lymphocytic lymphoma (SLL) was also present in the same lymph node and in the bone marrow. B- and T-cell gene rearrangement studies by PCR show the MCL and SLL to be clonally related. Expression of multiple aberrant antigens and concurrent lymphomas of different classifications can cause a diagnostic challenge. Awareness of such a presentation and integration of the data from morphologic evaluation, flow cytometry, immunohistochemistry, and FISH studies is required for proper diagnosis, prognosis, and therapy. |
| format | Article |
| id | doaj-art-bf6d9385e2ca4f4cbcdabb07d30e9ca3 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-bf6d9385e2ca4f4cbcdabb07d30e9ca32025-02-03T01:01:58ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/83035718303571Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene RearrangementsChristopher L. Felten0Joel A. Chan1Dulce R. DeCastro2Jean Lopategui3Swapnil P. Rajurkar4Gemini Diagnostics Hematopathology, 756 Lakefield Road Suite C, Westlake Village, CA 91361, USAGemini Diagnostics Hematopathology, 756 Lakefield Road Suite C, Westlake Village, CA 91361, USASan Antonio Regional Hospital, Department of Pathology, 999 San Bernardino Road, Upland, CA 91786, USACedars-Sinai Medical Center, Department of Pathology, 8700 Beverly Boulevard, Los Angeles, CA 90048, USAMedical Oncology and Hematology, 7777 Milliken Avenue Suite 210, Rancho Cucamonga, CA 91730, USAMantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. We report a blastoid variant of mantle cell lymphoma (MCL) involving an inguinal lymph node that, in addition to classical phenotypic and genetic findings, also aberrantly coexpresses surface CD10 and cytoplasmic CD3. Small lymphocytic lymphoma (SLL) was also present in the same lymph node and in the bone marrow. B- and T-cell gene rearrangement studies by PCR show the MCL and SLL to be clonally related. Expression of multiple aberrant antigens and concurrent lymphomas of different classifications can cause a diagnostic challenge. Awareness of such a presentation and integration of the data from morphologic evaluation, flow cytometry, immunohistochemistry, and FISH studies is required for proper diagnosis, prognosis, and therapy.http://dx.doi.org/10.1155/2018/8303571 |
| spellingShingle | Christopher L. Felten Joel A. Chan Dulce R. DeCastro Jean Lopategui Swapnil P. Rajurkar Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements Case Reports in Hematology |
| title | Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements |
| title_full | Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements |
| title_fullStr | Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements |
| title_full_unstemmed | Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements |
| title_short | Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements |
| title_sort | blastoid variant mantle cell lymphoma expressing aberrant cd3 and cd10 with concurrent small lymphocytic lymphoma establishment of a clonal relationship by b and t cell receptor gene rearrangements |
| url | http://dx.doi.org/10.1155/2018/8303571 |
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