Huoshan Dendrobium Zengye Jiedu Formula mitigates radiation-induced oral mucositis and improves oral immune microenvironment by targeting the EGFR/PI3K/AKT pathway: evidence from network pharmacology, molecular docking, and experimental validation

Huoshan Dendrobium Zengye Jiedu Formula mitigates radiation-induced oral mucositis and improves oral immune microenvironment by targeting the EGFR/PI3K/AKT pathway: evidence from network pharmacology, molecular docking, and experimental validation

IntroductionRadiation-induced oral mucositis (RIOM) manifests as mucosal ulceration, pain, and dysphagia, disrupting treatment and quality of life. Its pathogenesis involves inflammatory imbalance and immune dysregulation, driven by microbial infiltration and cytokine storms. Current therapies remai...

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Bibliographic Details
Main Authors: Chang Liu, Xinru Liu, Jiabao Liu, Hao Zhang, Pengcheng Zhang, Xingxing Huo, Hang Song, Yongfu Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
radiation-induced oral mucositis
pharmacological mechanism
network pharmacology
molecular docking
experimental validation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1559400/full
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