Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World Practice
<b>Background/Objectives</b>: To describe the effects of muscle-targeted oral nutritional supplementation (MT-ONS) on nutrition, functional capacity, and other health outcomes in patients after femur fracture surgery. <b>Methods</b>: A prospective, open-label, single-centre s...
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MDPI AG
2024-11-01
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| Series: | Geriatrics |
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| Online Access: | https://www.mdpi.com/2308-3417/9/6/153 |
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| author | Francisco José Soria Perdomo Sara Fernández Villaseca Cristina Zaragoza Brehcist Elena García Gómez |
| author_facet | Francisco José Soria Perdomo Sara Fernández Villaseca Cristina Zaragoza Brehcist Elena García Gómez |
| author_sort | Francisco José Soria Perdomo |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: To describe the effects of muscle-targeted oral nutritional supplementation (MT-ONS) on nutrition, functional capacity, and other health outcomes in patients after femur fracture surgery. <b>Methods</b>: A prospective, open-label, single-centre study was conducted. Patients aged 80+ post-femur fracture were recruited. They were assessed at baseline and after 90 days with MT-ONS, 100% whey protein enriched with leucine and vitamin D. Demographics, clinical and nutritional status (MNA<sup>®</sup>-SF), functional capacity [Barthel Index (BI), Lawton and Brody (LB) scale], muscle strength (dynamometry), cognition [Global Deterioration Scale (GDS)], tolerability, and satisfaction data were collected. Descriptive statistics were performed. Ethical approval was obtained. <b>Results</b>: Thirty-one patients (74% women, mean age 87 ± 3.99 years) were enrolled. At baseline, 32% were malnourished and 65% were at risk. After ≥90 days of MT-ONS, malnutrition decreased to 13% and well-nourishment increased to 32%. Ninety percent gained weight, with significant muscle strength improvements (+2 kg, <i>p</i> < 0.001). Eighty-one percent achieved a BI score ≥ 60 points [mean 84.8 (±17.82)]. BI score improvements correlated with higher baseline muscle strength (rho = 0.413, <i>p</i> = 0.021) and better nutritional status (rho = 0.464, <i>p</i> = 0.009). The mean LB score was 4.84 (±2.26). Improvements correlated with the pre-fracture BI score (rho = 0.475, <i>p</i> = 0.007). Positive correlations were noted between nutritional status, muscle strength, and functional outcomes. Cognition remained stable (GDS = 1 in 67.7% patients). Tolerability and satisfaction with MT-ONS were high at 90%. <b>Conclusions</b>: MT-ONS, 100% whey protein enriched with leucine and vitamin D, for ≥90 days enhances nutritional status and functional recovery in patients after femur fracture surgery. |
| format | Article |
| id | doaj-art-bf65d0c3c1f64c70b354bc77cc877ac8 |
| institution | OA Journals |
| issn | 2308-3417 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Geriatrics |
| spelling | doaj-art-bf65d0c3c1f64c70b354bc77cc877ac82025-08-20T02:00:27ZengMDPI AGGeriatrics2308-34172024-11-019615310.3390/geriatrics9060153Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World PracticeFrancisco José Soria Perdomo0Sara Fernández Villaseca1Cristina Zaragoza Brehcist2Elena García Gómez3Geriatrics Department, 12 de Octubre University Hospital, 28041 Madrid, SpainGeriatrics Department, 12 de Octubre University Hospital, 28041 Madrid, SpainGeriatrics Department, 12 de Octubre University Hospital, 28041 Madrid, SpainGeriatrics Department, 12 de Octubre University Hospital, 28041 Madrid, Spain<b>Background/Objectives</b>: To describe the effects of muscle-targeted oral nutritional supplementation (MT-ONS) on nutrition, functional capacity, and other health outcomes in patients after femur fracture surgery. <b>Methods</b>: A prospective, open-label, single-centre study was conducted. Patients aged 80+ post-femur fracture were recruited. They were assessed at baseline and after 90 days with MT-ONS, 100% whey protein enriched with leucine and vitamin D. Demographics, clinical and nutritional status (MNA<sup>®</sup>-SF), functional capacity [Barthel Index (BI), Lawton and Brody (LB) scale], muscle strength (dynamometry), cognition [Global Deterioration Scale (GDS)], tolerability, and satisfaction data were collected. Descriptive statistics were performed. Ethical approval was obtained. <b>Results</b>: Thirty-one patients (74% women, mean age 87 ± 3.99 years) were enrolled. At baseline, 32% were malnourished and 65% were at risk. After ≥90 days of MT-ONS, malnutrition decreased to 13% and well-nourishment increased to 32%. Ninety percent gained weight, with significant muscle strength improvements (+2 kg, <i>p</i> < 0.001). Eighty-one percent achieved a BI score ≥ 60 points [mean 84.8 (±17.82)]. BI score improvements correlated with higher baseline muscle strength (rho = 0.413, <i>p</i> = 0.021) and better nutritional status (rho = 0.464, <i>p</i> = 0.009). The mean LB score was 4.84 (±2.26). Improvements correlated with the pre-fracture BI score (rho = 0.475, <i>p</i> = 0.007). Positive correlations were noted between nutritional status, muscle strength, and functional outcomes. Cognition remained stable (GDS = 1 in 67.7% patients). Tolerability and satisfaction with MT-ONS were high at 90%. <b>Conclusions</b>: MT-ONS, 100% whey protein enriched with leucine and vitamin D, for ≥90 days enhances nutritional status and functional recovery in patients after femur fracture surgery.https://www.mdpi.com/2308-3417/9/6/153muscle targeted oral nutritional supplementationfemur fracturenutritional statusfunctional capacity |
| spellingShingle | Francisco José Soria Perdomo Sara Fernández Villaseca Cristina Zaragoza Brehcist Elena García Gómez Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World Practice Geriatrics muscle targeted oral nutritional supplementation femur fracture nutritional status functional capacity |
| title | Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World Practice |
| title_full | Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World Practice |
| title_fullStr | Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World Practice |
| title_full_unstemmed | Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World Practice |
| title_short | Enhanced Nutritional and Functional Recovery in Femur Fracture Patients Post-Surgery: Preliminary Evidence of Muscle-Targeted Nutritional Support in Real-World Practice |
| title_sort | enhanced nutritional and functional recovery in femur fracture patients post surgery preliminary evidence of muscle targeted nutritional support in real world practice |
| topic | muscle targeted oral nutritional supplementation femur fracture nutritional status functional capacity |
| url | https://www.mdpi.com/2308-3417/9/6/153 |
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