The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency
Introduction. Vitamin D deficiency may be an independent predictor of coronary heart disease (CHD) and the severity of coronary atherosclerosis. The results of studies of the association of various polymorphisms of the vitamin D receptor (VDR) gene with the risk and severity of CHD are contradictory...
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Academician I.P. Pavlov First St. Petersburg State Medical University
2022-07-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/866 |
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| author | O. D. Belyaeva J. Du Zh. I. Ionova T. L. Karonova E. V. Polunicheva V. V. Miroshnikova K. V. Dracheva T. T. Khachikyan S. N. Pchelina O. V. Listopad O. A. Berkovich |
| author_facet | O. D. Belyaeva J. Du Zh. I. Ionova T. L. Karonova E. V. Polunicheva V. V. Miroshnikova K. V. Dracheva T. T. Khachikyan S. N. Pchelina O. V. Listopad O. A. Berkovich |
| author_sort | O. D. Belyaeva |
| collection | DOAJ |
| description | Introduction. Vitamin D deficiency may be an independent predictor of coronary heart disease (CHD) and the severity of coronary atherosclerosis. The results of studies of the association of various polymorphisms of the vitamin D receptor (VDR) gene with the risk and severity of CHD are contradictory, which necessitates the study of genetic variants of the VDR gene and the characteristics of the clinical course of CHD in the Russian population.The objective was to determine the distribution of genotypes of TaqI, BsmI and ApaI of polymorphic variants of the VDR gene and the level of vitamin D sufficiency in CHD patients with varying severity of CHD, residents of St. Petersburg.Methods and materials. The study included 407 CHD patients and 318 patients without clinical signs of CHD of comparable age (p>0.05). All CHD patients underwent coronary angiography. Typing of the VDR gene variants was performed by polymerase chain reaction and subsequent restriction analysis. Determination of the level of 25(OH)D blood serum was carried out by enzyme immunoassay.Results. Vitamin D deficiency was detected in 82 % of CHD patients, the content of 25(OH)D in blood serum was lower in CHD patients who had 2 or more myocardial infarctions (MI) than in those who had one MI (p=0.03). Vitamin D deficiency is associated with a 3.6-fold increased risk of multivessel disease (p=0.01). The presence of the aa genotype and the a allele (ApaI), the bb genotype and the b allele of the VDR gene (BsmI) is associated with an increased risk of CHD and the severity of atherosclerotic lesions of the coronary arteries.Conclusion. Vitamin D deficiency is typical for CHD patients and is associated with the severity of coronary atherosclerosis. The presence of aa genotype and a allele (ApaI polymorphism), bb genotype and b allele of the VDR gene (BsmI polymorphism) is associated with an increased risk of CHD and the severity of atherosclerotic lesions of the coronary arteries. TaqI polymorphism of the VDR gene is not associated with the risk of CHD. |
| format | Article |
| id | doaj-art-bf65af526ca94fb98a6d93f43deb0040 |
| institution | DOAJ |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-bf65af526ca94fb98a6d93f43deb00402025-08-20T03:00:36ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072022-07-01292415110.24884/1607-4181-2022-29-2-41-51585The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiencyO. D. Belyaeva0J. Du1Zh. I. Ionova2T. L. Karonova3E. V. Polunicheva4V. V. Miroshnikova5K. V. Dracheva6T. T. Khachikyan7S. N. Pchelina8O. V. Listopad9O. A. Berkovich10Pavlov UniversityPavlov UniversityPavlov UniversityPavlov UniversityPavlov UniversityPavlov UniversityPavlov UniversityPavlov UniversityPavlov UniversityPavlov UniversityPavlov UniversityIntroduction. Vitamin D deficiency may be an independent predictor of coronary heart disease (CHD) and the severity of coronary atherosclerosis. The results of studies of the association of various polymorphisms of the vitamin D receptor (VDR) gene with the risk and severity of CHD are contradictory, which necessitates the study of genetic variants of the VDR gene and the characteristics of the clinical course of CHD in the Russian population.The objective was to determine the distribution of genotypes of TaqI, BsmI and ApaI of polymorphic variants of the VDR gene and the level of vitamin D sufficiency in CHD patients with varying severity of CHD, residents of St. Petersburg.Methods and materials. The study included 407 CHD patients and 318 patients without clinical signs of CHD of comparable age (p>0.05). All CHD patients underwent coronary angiography. Typing of the VDR gene variants was performed by polymerase chain reaction and subsequent restriction analysis. Determination of the level of 25(OH)D blood serum was carried out by enzyme immunoassay.Results. Vitamin D deficiency was detected in 82 % of CHD patients, the content of 25(OH)D in blood serum was lower in CHD patients who had 2 or more myocardial infarctions (MI) than in those who had one MI (p=0.03). Vitamin D deficiency is associated with a 3.6-fold increased risk of multivessel disease (p=0.01). The presence of the aa genotype and the a allele (ApaI), the bb genotype and the b allele of the VDR gene (BsmI) is associated with an increased risk of CHD and the severity of atherosclerotic lesions of the coronary arteries.Conclusion. Vitamin D deficiency is typical for CHD patients and is associated with the severity of coronary atherosclerosis. The presence of aa genotype and a allele (ApaI polymorphism), bb genotype and b allele of the VDR gene (BsmI polymorphism) is associated with an increased risk of CHD and the severity of atherosclerotic lesions of the coronary arteries. TaqI polymorphism of the VDR gene is not associated with the risk of CHD.https://www.sci-notes.ru/jour/article/view/866vitamin dcoronary heart diseasevitamin d deficiencyvitamin d receptor gene |
| spellingShingle | O. D. Belyaeva J. Du Zh. I. Ionova T. L. Karonova E. V. Polunicheva V. V. Miroshnikova K. V. Dracheva T. T. Khachikyan S. N. Pchelina O. V. Listopad O. A. Berkovich The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова vitamin d coronary heart disease vitamin d deficiency vitamin d receptor gene |
| title | The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency |
| title_full | The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency |
| title_fullStr | The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency |
| title_full_unstemmed | The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency |
| title_short | The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency |
| title_sort | severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin d receptor gene and the level of vitamin d sufficiency |
| topic | vitamin d coronary heart disease vitamin d deficiency vitamin d receptor gene |
| url | https://www.sci-notes.ru/jour/article/view/866 |
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