Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review
Early-onset Preeclampsia (EOPE) is a severe pregnancy complication that poses significant risks to both maternal and fetal health, often leading to fetal growth restriction and maternal morbidity. Despite extensive research, the etiology of EOPE remains unclear, though emerging evidence suggests tha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1598691/full |
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| author | Shu Zheng Shuai Dong Huimin Shen Peng Xu Chang Shu |
| author_facet | Shu Zheng Shuai Dong Huimin Shen Peng Xu Chang Shu |
| author_sort | Shu Zheng |
| collection | DOAJ |
| description | Early-onset Preeclampsia (EOPE) is a severe pregnancy complication that poses significant risks to both maternal and fetal health, often leading to fetal growth restriction and maternal morbidity. Despite extensive research, the etiology of EOPE remains unclear, though emerging evidence suggests that vitamin D (VD) may play an important role in placental development and function. Recent studies associate VD deficiency with adverse pregnancy outcomes, including EOPE, through mechanisms such as impaired trophoblast invasion and immune dysregulation at the maternal-fetal interface. This review aimed to synthesize current literature on the role of VD in the pathogenesis of EOPE. We reviewed in vitro, in vivo, and clinical studies to evaluate the impact of VD on immune modulation, angiogenesis, oxidative stress, and trophoblast migration and invasion in the placenta. This comprehensive review aims to provide insights into how VD deficiency exacerbates placental dysfunction, contributing to the development of EOPE. These insights support the rationale for VD supplementation as a potential preventive strategy and highlight the need for further clinical investigation. |
| format | Article |
| id | doaj-art-bf644148ecdd45bcbce7f2bd87ea4fa1 |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-bf644148ecdd45bcbce7f2bd87ea4fa12025-08-20T03:21:51ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-06-011210.3389/fnut.2025.15986911598691Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative reviewShu ZhengShuai DongHuimin ShenPeng XuChang ShuEarly-onset Preeclampsia (EOPE) is a severe pregnancy complication that poses significant risks to both maternal and fetal health, often leading to fetal growth restriction and maternal morbidity. Despite extensive research, the etiology of EOPE remains unclear, though emerging evidence suggests that vitamin D (VD) may play an important role in placental development and function. Recent studies associate VD deficiency with adverse pregnancy outcomes, including EOPE, through mechanisms such as impaired trophoblast invasion and immune dysregulation at the maternal-fetal interface. This review aimed to synthesize current literature on the role of VD in the pathogenesis of EOPE. We reviewed in vitro, in vivo, and clinical studies to evaluate the impact of VD on immune modulation, angiogenesis, oxidative stress, and trophoblast migration and invasion in the placenta. This comprehensive review aims to provide insights into how VD deficiency exacerbates placental dysfunction, contributing to the development of EOPE. These insights support the rationale for VD supplementation as a potential preventive strategy and highlight the need for further clinical investigation.https://www.frontiersin.org/articles/10.3389/fnut.2025.1598691/fullvitamin Dearly-onset preeclampsiaplacental angiogenesisoxidative stressimmune modulation |
| spellingShingle | Shu Zheng Shuai Dong Huimin Shen Peng Xu Chang Shu Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review Frontiers in Nutrition vitamin D early-onset preeclampsia placental angiogenesis oxidative stress immune modulation |
| title | Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review |
| title_full | Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review |
| title_fullStr | Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review |
| title_full_unstemmed | Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review |
| title_short | Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review |
| title_sort | role of vitamin d in the pathogenesis of early onset preeclampsia a narrative review |
| topic | vitamin D early-onset preeclampsia placental angiogenesis oxidative stress immune modulation |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1598691/full |
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