Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter Study
Background and Aim. Treatment adherence is a frequent problem in inflammatory bowel disease (IBD). No study has assessed adherence in Argentinian patients with IBD. The aim of this study was to determine inadequate adherence to oral and parenteral therapies in patients with IBD from Argentina and to...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/4060648 |
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| author | Juan Lasa Gustavo Correa Claudia Fuxman Laura Garbi Maria Eugenia Linares Pablo Lubrano Astrid Rausch Martin Toro Martin Yantorno Ignacio Zubiaurre Laurent Peyrin-Biroulet Pablo Olivera |
| author_facet | Juan Lasa Gustavo Correa Claudia Fuxman Laura Garbi Maria Eugenia Linares Pablo Lubrano Astrid Rausch Martin Toro Martin Yantorno Ignacio Zubiaurre Laurent Peyrin-Biroulet Pablo Olivera |
| author_sort | Juan Lasa |
| collection | DOAJ |
| description | Background and Aim. Treatment adherence is a frequent problem in inflammatory bowel disease (IBD). No study has assessed adherence in Argentinian patients with IBD. The aim of this study was to determine inadequate adherence to oral and parenteral therapies in patients with IBD from Argentina and to identify factors associated with it. Methods. A multicenter cross-sectional study involving seven referral centers from three cities of Argentina was undertaken. Patients with a diagnosis of ulcerative colitis (UC), Crohn’s disease (CD), or indeterminate colitis (IBDU/IC) were invited to answer an anonymous survey, which included a 5-point Likert scale to evaluate adherence to therapies. Independent variables associated with inadequate adherence were evaluated. Results. Overall, 447 UC/IBDU and 135 CD patients were enrolled. Median age was 37 years (range 21-72); 39.8% were male; median time from diagnosis was 6 years (0.5-35). 91.4% were under treatment with at least one oral medication; 50.3% of patients reported inadequate adherence to oral medications. Patients with UC/IBDU had a lower risk of inadequate adherence when compared to patients with CD (OR 0.57 (0.37-0.87)). 21.8% reported inadequate adherence to biologics; subcutaneous administration was significantly associated with inadequate adherence to biologics (OR 4.8 (1.57-14.66)). Conclusion. Inadequate treatment adherence is common among patients with IBD, and potentially modifiable factors were identified. |
| format | Article |
| id | doaj-art-bf62a0a77ce9410d8bbc93cdb0352502 |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-bf62a0a77ce9410d8bbc93cdb03525022025-08-20T03:23:08ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/40606484060648Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter StudyJuan Lasa0Gustavo Correa1Claudia Fuxman2Laura Garbi3Maria Eugenia Linares4Pablo Lubrano5Astrid Rausch6Martin Toro7Martin Yantorno8Ignacio Zubiaurre9Laurent Peyrin-Biroulet10Pablo Olivera11Gastroenterology Department, Hospital Britanico de Buenos Aires, Buenos Aires, ArgentinaGastroenterology Department, Hospital Interzonal General de Agudos “General José de San Martín”, La Plata, ArgentinaGastroenterology Department, Hospital Universitario Fundacion Favaloro, Buenos Aires, ArgentinaGastroenterology Department, Hospital Interzonal General de Agudos “General José de San Martín”, La Plata, ArgentinaGastroenterology Department, Hospital de Clínicas “José de San Martín”, Buenos Aires, ArgentinaGastroenterology Department, Sanatorio Mater Dei, Buenos Aires, ArgentinaGastroenterology Department, Hospital Britanico de Buenos Aires, Buenos Aires, ArgentinaGastroenterology Department, Hospital Universitario, Universidad Nacional de Cuyo, Mendoza, ArgentinaGastroenterology Department, Hospital Interzonal General de Agudos “General José de San Martín”, La Plata, ArgentinaGastroenterology Department, Hospital Britanico de Buenos Aires, Buenos Aires, ArgentinaINSERM U954 and Department of Hepatogastroenterology, Nancy University Hospital, Université de Lorraine, Vandoeuvre-lès-Nancy, FranceGastroenterology Section, Department of Internal Medicine, Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, ArgentinaBackground and Aim. Treatment adherence is a frequent problem in inflammatory bowel disease (IBD). No study has assessed adherence in Argentinian patients with IBD. The aim of this study was to determine inadequate adherence to oral and parenteral therapies in patients with IBD from Argentina and to identify factors associated with it. Methods. A multicenter cross-sectional study involving seven referral centers from three cities of Argentina was undertaken. Patients with a diagnosis of ulcerative colitis (UC), Crohn’s disease (CD), or indeterminate colitis (IBDU/IC) were invited to answer an anonymous survey, which included a 5-point Likert scale to evaluate adherence to therapies. Independent variables associated with inadequate adherence were evaluated. Results. Overall, 447 UC/IBDU and 135 CD patients were enrolled. Median age was 37 years (range 21-72); 39.8% were male; median time from diagnosis was 6 years (0.5-35). 91.4% were under treatment with at least one oral medication; 50.3% of patients reported inadequate adherence to oral medications. Patients with UC/IBDU had a lower risk of inadequate adherence when compared to patients with CD (OR 0.57 (0.37-0.87)). 21.8% reported inadequate adherence to biologics; subcutaneous administration was significantly associated with inadequate adherence to biologics (OR 4.8 (1.57-14.66)). Conclusion. Inadequate treatment adherence is common among patients with IBD, and potentially modifiable factors were identified.http://dx.doi.org/10.1155/2020/4060648 |
| spellingShingle | Juan Lasa Gustavo Correa Claudia Fuxman Laura Garbi Maria Eugenia Linares Pablo Lubrano Astrid Rausch Martin Toro Martin Yantorno Ignacio Zubiaurre Laurent Peyrin-Biroulet Pablo Olivera Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter Study Gastroenterology Research and Practice |
| title | Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter Study |
| title_full | Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter Study |
| title_fullStr | Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter Study |
| title_full_unstemmed | Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter Study |
| title_short | Treatment Adherence in Inflammatory Bowel Disease Patients from Argentina: A Multicenter Study |
| title_sort | treatment adherence in inflammatory bowel disease patients from argentina a multicenter study |
| url | http://dx.doi.org/10.1155/2020/4060648 |
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