Spatiotemporal molecular tracing of ultralow-volume biofluids via a soft skin-adaptive optical monolithic patch sensor
Abstract Molecular tracing of extremely low amounts of biofluids is vital for precise diagnostic analysis. Although optical nanosensors for real-time spatiotemporal molecular tracing exist, integrating them into simple devices that capture low-volume fluids on rough, dynamic surfaces remains challen...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58425-x |
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| Summary: | Abstract Molecular tracing of extremely low amounts of biofluids is vital for precise diagnostic analysis. Although optical nanosensors for real-time spatiotemporal molecular tracing exist, integrating them into simple devices that capture low-volume fluids on rough, dynamic surfaces remains challenging. We present a bioinspired 3D microstructured patch monolithically integrated with optical nanosensors (3D MIN) for real-time, multivariate molecular tracing of ultralow-volume fluids. Inspired by tree frog toe pads, the 3D MIN features soft, hexagonally aligned pillars and microchannels for conformal adhesion and targeted fluid management. Embedding near-infrared fluorescent single-walled carbon nanotube nanosensors in a hydrogel enables simultaneous fluid capture and detection. Softening the elastomer microarchitecture and optimizing water management promote stable adhesion on wet biosurfaces, allowing rapid collection of ultralow-volume fluids (~0.1 µL/min·cm²). We demonstrate real-time, remote sweat analysis with ≥75 nL volumes collected in 45 s, without exercise or iontophoresis, showcasing high biocompatibility and efficient spatiotemporal molecular tracing. |
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| ISSN: | 2041-1723 |