Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination

Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination

Abstract Melanoma is a serious type of skin cancer that originates from melanocytes. Rodent melanoma models have provided valuable insights into melanoma pathology; however, they often lack applicability to humans owing to genetic, anatomical, physiological, and metabolic differences. Herein, we dev...

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Main Authors: Dongjin Oh, Nayoung Hong, Kiyoung Eun, Joohyeong Lee, Lian Cai, Mirae Kim, Hyerin Choi, Ali Jawad, Jaehyung Ham, Min Gi Park, Bohye Kim, Sang Chul Lee, Changjong Moon, Hyunggee Kim, Sang-Hwan Hyun
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Melanoma
Transgenic cancer model
Pig
Tissue-specific activation
Somatic cell nuclear transfer
Online Access:https://doi.org/10.1038/s41598-024-82554-w
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