Elevated BP180 ELISA at Diagnosis Correlates with Disease Severity and Relapse in Oral Mucous Membrane Pemphigoid: Preliminary Results from a Retrospective Monocentric Italian Study
Background: Little is known about the relevance of BP180 ELISA for the clinical management of oral mucous membrane pemphigoid (OMMP). The aim of the present study was to investigate if the levels of anti-BP180 antibodies at diagnosis could be correlated with clinical severity and relapse. Methods: T...
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| author | Andrea Gabusi Davide B. Gissi Roberto Rossi Federica Filippi Camilla Loi Cosimo Misciali Giacomo Clarizio Michelangelo La Placa Federico Bardazzi |
| author_facet | Andrea Gabusi Davide B. Gissi Roberto Rossi Federica Filippi Camilla Loi Cosimo Misciali Giacomo Clarizio Michelangelo La Placa Federico Bardazzi |
| author_sort | Andrea Gabusi |
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| description | Background: Little is known about the relevance of BP180 ELISA for the clinical management of oral mucous membrane pemphigoid (OMMP). The aim of the present study was to investigate if the levels of anti-BP180 antibodies at diagnosis could be correlated with clinical severity and relapse. Methods: The present study included 44 OMMP patients with positive direct immunofluorescence (DIF). Circulating anti-BP180 IgG was measured using the same available ELISA kit (Euroimmun cut-off 20 U/mL). Clinical severity at diagnosis was measured using the oral disease severity score (ODSS). Only patients who achieved clinical remission (CR) were included in the analysis of variables related to relapse. Relapse was calculated as the interval between the date of the best type of clinical remission achieved and the date of relapse. Results: Values of BP180 > 20 U/mL significantly correlated with higher ODSSs in both univariate (<i>p</i> < 0.05) and multivariate analyses (<i>p</i> < 0.05). Among 39/44 patients who achieved CR, 17/39 relapsed. Kaplan–Meier analysis revealed that patients with BP180 > 20 U/mL displayed worse clinical behavior in terms of relapse (<i>p</i> < 0.05). Conclusion: BP180 ELISA at diagnosis appears to be a useful parameter to stratify OMMP patients with more severe disease and worse clinical outcomes after clinical remission. |
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| institution | Kabale University |
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| publishDate | 2025-01-01 |
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| spelling | doaj-art-bf620a91527041e2bc54473cb8d35c1e2025-01-24T13:20:29ZengMDPI AGApplied Sciences2076-34172025-01-0115268910.3390/app15020689Elevated BP180 ELISA at Diagnosis Correlates with Disease Severity and Relapse in Oral Mucous Membrane Pemphigoid: Preliminary Results from a Retrospective Monocentric Italian StudyAndrea Gabusi0Davide B. Gissi1Roberto Rossi2Federica Filippi3Camilla Loi4Cosimo Misciali5Giacomo Clarizio6Michelangelo La Placa7Federico Bardazzi8Section of Oral Sciences, Department of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, ItalySection of Oral Sciences, Department of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, ItalySection of Oral Sciences, Department of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, ItalyDivision of Dermatology, Department of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, ItalyDivision of Dermatology, Department of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, ItalyDivision of Dermatology, Department of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, ItalyDivision of Dermatology, Department of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, ItalyDivision of Dermatology, Department of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, ItalyDivision of Dermatology, Department of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, ItalyBackground: Little is known about the relevance of BP180 ELISA for the clinical management of oral mucous membrane pemphigoid (OMMP). The aim of the present study was to investigate if the levels of anti-BP180 antibodies at diagnosis could be correlated with clinical severity and relapse. Methods: The present study included 44 OMMP patients with positive direct immunofluorescence (DIF). Circulating anti-BP180 IgG was measured using the same available ELISA kit (Euroimmun cut-off 20 U/mL). Clinical severity at diagnosis was measured using the oral disease severity score (ODSS). Only patients who achieved clinical remission (CR) were included in the analysis of variables related to relapse. Relapse was calculated as the interval between the date of the best type of clinical remission achieved and the date of relapse. Results: Values of BP180 > 20 U/mL significantly correlated with higher ODSSs in both univariate (<i>p</i> < 0.05) and multivariate analyses (<i>p</i> < 0.05). Among 39/44 patients who achieved CR, 17/39 relapsed. Kaplan–Meier analysis revealed that patients with BP180 > 20 U/mL displayed worse clinical behavior in terms of relapse (<i>p</i> < 0.05). Conclusion: BP180 ELISA at diagnosis appears to be a useful parameter to stratify OMMP patients with more severe disease and worse clinical outcomes after clinical remission.https://www.mdpi.com/2076-3417/15/2/689mucous membrane pemphigoidoral cavityBP180ELISAclinical severity |
| spellingShingle | Andrea Gabusi Davide B. Gissi Roberto Rossi Federica Filippi Camilla Loi Cosimo Misciali Giacomo Clarizio Michelangelo La Placa Federico Bardazzi Elevated BP180 ELISA at Diagnosis Correlates with Disease Severity and Relapse in Oral Mucous Membrane Pemphigoid: Preliminary Results from a Retrospective Monocentric Italian Study Applied Sciences mucous membrane pemphigoid oral cavity BP180 ELISA clinical severity |
| title | Elevated BP180 ELISA at Diagnosis Correlates with Disease Severity and Relapse in Oral Mucous Membrane Pemphigoid: Preliminary Results from a Retrospective Monocentric Italian Study |
| title_full | Elevated BP180 ELISA at Diagnosis Correlates with Disease Severity and Relapse in Oral Mucous Membrane Pemphigoid: Preliminary Results from a Retrospective Monocentric Italian Study |
| title_fullStr | Elevated BP180 ELISA at Diagnosis Correlates with Disease Severity and Relapse in Oral Mucous Membrane Pemphigoid: Preliminary Results from a Retrospective Monocentric Italian Study |
| title_full_unstemmed | Elevated BP180 ELISA at Diagnosis Correlates with Disease Severity and Relapse in Oral Mucous Membrane Pemphigoid: Preliminary Results from a Retrospective Monocentric Italian Study |
| title_short | Elevated BP180 ELISA at Diagnosis Correlates with Disease Severity and Relapse in Oral Mucous Membrane Pemphigoid: Preliminary Results from a Retrospective Monocentric Italian Study |
| title_sort | elevated bp180 elisa at diagnosis correlates with disease severity and relapse in oral mucous membrane pemphigoid preliminary results from a retrospective monocentric italian study |
| topic | mucous membrane pemphigoid oral cavity BP180 ELISA clinical severity |
| url | https://www.mdpi.com/2076-3417/15/2/689 |
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