Sensitive detection of minimal residual disease and immunotherapy targets by multi-modal bone marrow analysis in high-risk neuroblastoma – a multi-center study

Sensitive detection of minimal residual disease and immunotherapy targets by multi-modal bone marrow analysis in high-risk neuroblastoma – a multi-center study

Abstract Background Bone marrow dissemination of tumor cells, common in various cancers, including neuroblastoma, is associated with poor outcome, necessitating sensitive detection methods for bone marrow minimal residual disease (MRD) and offer detection of biomarkers for therapy stratification. Cu...

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Main Authors: Nina U. Gelineau, Eva Bozsaky, Lieke M. J. van Zogchel, Fikret Rifatbegovic, Daria Lazic, Andrea Ziegler, Ahmad Javadi, Lily Zappeij-Kannegieter, Ulrike Pötschger, Marta Fiocco, Peter F. Ambros, Inge M. Ambros, Bernd Bodenmiller, Ellen C. van der Schoot, Ruth Ladenstein, Marie Bernkopf, Godelieve A. M. Tytgat, Sabine Taschner-Mandl
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Neuroblastoma
Liquid biopsies
Minimal residual disease
Bone marrow
RT-qPCR
Automated immunofluorescence
Online Access:https://doi.org/10.1186/s13046-025-03481-w
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