Hypertension attenuates COVID-19 vaccine protection in elderly patients: a retrospective cohort study
The COVID-19 pandemic has severely impacted elderly populations, particularly those with comorbidities. This study evaluated the effects of COVID-19 vaccination on 193 hospitalized elderly patients (≥ 60 years) in Macao. Vaccination was suggestively associated with a 2.3-fold higher likelihood of pr...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612205/full |
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| Summary: | The COVID-19 pandemic has severely impacted elderly populations, particularly those with comorbidities. This study evaluated the effects of COVID-19 vaccination on 193 hospitalized elderly patients (≥ 60 years) in Macao. Vaccination was suggestively associated with a 2.3-fold higher likelihood of prognostic improvement (adjusted OR = 2.3, 95% CI: 0.980-5.940, P = 0.065), while hypertension significantly reduced the improvement rate by 67.5% (P = 0.039). Vaccinated patients also exhibited lower Modified Early Warning Scores and reduced mortality. These findings underscore the protective role of vaccination in improving prognosis among high-risk elderly patients and highlight the need for tailored strategies for those with comorbidities. |
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| ISSN: | 1664-3224 |