Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood.
<h4>Background</h4>Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the...
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138920&type=printable |
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| author | Lauren E Wilson Sangmi Kim Zongli Xu Sophia Harlid Dale P Sandler Jack A Taylor |
| author_facet | Lauren E Wilson Sangmi Kim Zongli Xu Sophia Harlid Dale P Sandler Jack A Taylor |
| author_sort | Lauren E Wilson |
| collection | DOAJ |
| description | <h4>Background</h4>Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined.<h4>Findings</h4>Using the Sister Study cohort, we examined the association between NSAID usage and whole genome methylation patterns in blood DNA. Blood DNA methylation status across 27,589 CpG sites was evaluated for 871 women using the Illumina Infinium HumanMethylation27 Beadchip, and in a non-overlapping replication sample of 187 women at 485,512 CpG sites using the Infinium HumanMethylation450 Beadchip. We identified a number of CpG sites that were differentially methylated in regular, long-term users of NSAIDs in the discovery group, but none of these sites were statistically significant in our replication group.<h4>Conclusions</h4>We found no replicable methylation differences in blood related to NSAID usage. If NSAID use does effect blood DNA methylation patterns, differences are likely small. |
| format | Article |
| id | doaj-art-bf5f5ca8e5e845d4977603c0f13e141b |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-bf5f5ca8e5e845d4977603c0f13e141b2025-08-20T02:22:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013892010.1371/journal.pone.0138920Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood.Lauren E WilsonSangmi KimZongli XuSophia HarlidDale P SandlerJack A Taylor<h4>Background</h4>Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon cancer through this pathway; however, the effect of NSAID use on the DNA methylation profile of other tissues including whole blood has not yet been examined.<h4>Findings</h4>Using the Sister Study cohort, we examined the association between NSAID usage and whole genome methylation patterns in blood DNA. Blood DNA methylation status across 27,589 CpG sites was evaluated for 871 women using the Illumina Infinium HumanMethylation27 Beadchip, and in a non-overlapping replication sample of 187 women at 485,512 CpG sites using the Infinium HumanMethylation450 Beadchip. We identified a number of CpG sites that were differentially methylated in regular, long-term users of NSAIDs in the discovery group, but none of these sites were statistically significant in our replication group.<h4>Conclusions</h4>We found no replicable methylation differences in blood related to NSAID usage. If NSAID use does effect blood DNA methylation patterns, differences are likely small.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138920&type=printable |
| spellingShingle | Lauren E Wilson Sangmi Kim Zongli Xu Sophia Harlid Dale P Sandler Jack A Taylor Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood. PLoS ONE |
| title | Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood. |
| title_full | Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood. |
| title_fullStr | Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood. |
| title_full_unstemmed | Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood. |
| title_short | Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood. |
| title_sort | non steroidal anti inflammatory drug use and genomic dna methylation in blood |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138920&type=printable |
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