CCL7 promotes macrophage polarization and synovitis to exacerbate rheumatoid arthritis

CCL7 promotes macrophage polarization and synovitis to exacerbate rheumatoid arthritis

Summary: Chemokine C-C motif ligand 7 (CCL7) is implicated in various immune and inflammatory processes; however, its role in rheumatoid arthritis (RA) remains unclear. In this study, we observed that CCL7 expression was upregulated in synovial M1-polarized macrophages and in the serum of RA mice an...

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Bibliographic Details
Main Authors: Jun Chen, Shuo Shi, Xiaojia Li, Feng Gao, Xu Zhu, Ru Feng, Ke Hu, Yicheng Li, Shuiyuan Chen, Rongkai Zhang, Xiaoshuai Wang, Changhai Ding, Gang Liu, Tianyu Chen, Wenquan Liang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:iScience
Subjects:
natural sciences
biological sciences
immunology
immune system disorder
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225004389
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