Treatment tactic of canine cranial cruciate ligament rupture management: A 28-day comparative analysis of ACP and NSAID induced effects on the serum MMP-3 levels and clinical outcomes
Cranial cruciate ligament rupture (CrCLR) is a common stifle joint pathology among dogs, leading to osteoarthritis and painfulness. Non-surgical treatment options often represent the usage of non-steroidal anti-inflammatory drugs for 14 days (NSAIDs), but autologous conditioned plasma (ACP) shows pr...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Czech Academy of Agricultural Sciences
2025-04-01
|
| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-202504-0001_treatment-tactic-of-canine-cranial-cruciate-ligament-rupture-management-a-28-day-comparative-analysis-of-acp-a.php |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849314925969670144 |
|---|---|
| author | K Raulinaite R Zelvyte K Skemiene I Monkeviciene |
| author_facet | K Raulinaite R Zelvyte K Skemiene I Monkeviciene |
| author_sort | K Raulinaite |
| collection | DOAJ |
| description | Cranial cruciate ligament rupture (CrCLR) is a common stifle joint pathology among dogs, leading to osteoarthritis and painfulness. Non-surgical treatment options often represent the usage of non-steroidal anti-inflammatory drugs for 14 days (NSAIDs), but autologous conditioned plasma (ACP) shows promising results in managing various orthopaedic conditions, decreasing inflammation, and improving the clinical outcome in dogs. This study aimed to determine the differences in MMP-3 serum levels and the clinical outcomes between differently treated cranial cruciate rupture cases. For this purpose, we used two different treatment methods for managing canine cranial cruciate ligament rupture (minimally invasive ACP injection or oral NSAIDs), and evaluated the clinical outcomes, indicating the quality of life, and the MMP-3 serum levels over a period of 28 days. The findings of this investigation indicate that ACP has better efficacy than two weeks of NSAIDs in inflammation reduction, clinical outcome improvement, and the allowance of a longer duration of activity after 28 days. |
| format | Article |
| id | doaj-art-bf5dbf2aa3954ad98f9c5a078cbf2cda |
| institution | Kabale University |
| issn | 0375-8427 1805-9392 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj-art-bf5dbf2aa3954ad98f9c5a078cbf2cda2025-08-20T03:52:16ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922025-04-0170412413310.17221/39/2024-VETMEDvet-202504-0001Treatment tactic of canine cranial cruciate ligament rupture management: A 28-day comparative analysis of ACP and NSAID induced effects on the serum MMP-3 levels and clinical outcomesK Raulinaite0R Zelvyte1K Skemiene2I Monkeviciene3Department of Anatomy and Physiology, Faculty of Veterinary, Veterinary Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Anatomy and Physiology, Faculty of Veterinary, Veterinary Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaLaboratory of Biochemistry, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Anatomy and Physiology, Faculty of Veterinary, Veterinary Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaCranial cruciate ligament rupture (CrCLR) is a common stifle joint pathology among dogs, leading to osteoarthritis and painfulness. Non-surgical treatment options often represent the usage of non-steroidal anti-inflammatory drugs for 14 days (NSAIDs), but autologous conditioned plasma (ACP) shows promising results in managing various orthopaedic conditions, decreasing inflammation, and improving the clinical outcome in dogs. This study aimed to determine the differences in MMP-3 serum levels and the clinical outcomes between differently treated cranial cruciate rupture cases. For this purpose, we used two different treatment methods for managing canine cranial cruciate ligament rupture (minimally invasive ACP injection or oral NSAIDs), and evaluated the clinical outcomes, indicating the quality of life, and the MMP-3 serum levels over a period of 28 days. The findings of this investigation indicate that ACP has better efficacy than two weeks of NSAIDs in inflammation reduction, clinical outcome improvement, and the allowance of a longer duration of activity after 28 days.https://vetmed.agriculturejournals.cz/artkey/vet-202504-0001_treatment-tactic-of-canine-cranial-cruciate-ligament-rupture-management-a-28-day-comparative-analysis-of-acp-a.phpautologous conditioned plasmadogcranial cruciate ligament rupturefunctional outcomesmatrix metalloproteinase 3nonsteroidal anti-inflammatory drugs |
| spellingShingle | K Raulinaite R Zelvyte K Skemiene I Monkeviciene Treatment tactic of canine cranial cruciate ligament rupture management: A 28-day comparative analysis of ACP and NSAID induced effects on the serum MMP-3 levels and clinical outcomes Veterinární Medicína autologous conditioned plasma dog cranial cruciate ligament rupture functional outcomes matrix metalloproteinase 3 nonsteroidal anti-inflammatory drugs |
| title | Treatment tactic of canine cranial cruciate ligament rupture management: A 28-day comparative analysis of ACP and NSAID induced effects on the serum MMP-3 levels and clinical outcomes |
| title_full | Treatment tactic of canine cranial cruciate ligament rupture management: A 28-day comparative analysis of ACP and NSAID induced effects on the serum MMP-3 levels and clinical outcomes |
| title_fullStr | Treatment tactic of canine cranial cruciate ligament rupture management: A 28-day comparative analysis of ACP and NSAID induced effects on the serum MMP-3 levels and clinical outcomes |
| title_full_unstemmed | Treatment tactic of canine cranial cruciate ligament rupture management: A 28-day comparative analysis of ACP and NSAID induced effects on the serum MMP-3 levels and clinical outcomes |
| title_short | Treatment tactic of canine cranial cruciate ligament rupture management: A 28-day comparative analysis of ACP and NSAID induced effects on the serum MMP-3 levels and clinical outcomes |
| title_sort | treatment tactic of canine cranial cruciate ligament rupture management a 28 day comparative analysis of acp and nsaid induced effects on the serum mmp 3 levels and clinical outcomes |
| topic | autologous conditioned plasma dog cranial cruciate ligament rupture functional outcomes matrix metalloproteinase 3 nonsteroidal anti-inflammatory drugs |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-202504-0001_treatment-tactic-of-canine-cranial-cruciate-ligament-rupture-management-a-28-day-comparative-analysis-of-acp-a.php |
| work_keys_str_mv | AT kraulinaite treatmenttacticofcaninecranialcruciateligamentrupturemanagementa28daycomparativeanalysisofacpandnsaidinducedeffectsontheserummmp3levelsandclinicaloutcomes AT rzelvyte treatmenttacticofcaninecranialcruciateligamentrupturemanagementa28daycomparativeanalysisofacpandnsaidinducedeffectsontheserummmp3levelsandclinicaloutcomes AT kskemiene treatmenttacticofcaninecranialcruciateligamentrupturemanagementa28daycomparativeanalysisofacpandnsaidinducedeffectsontheserummmp3levelsandclinicaloutcomes AT imonkeviciene treatmenttacticofcaninecranialcruciateligamentrupturemanagementa28daycomparativeanalysisofacpandnsaidinducedeffectsontheserummmp3levelsandclinicaloutcomes |