Vitamin D impedes eosinophil chemotaxis via inhibiting glycolysis-induced CCL26 expression in eosinophilic chronic rhinosinusitis with nasal polyps

Vitamin D impedes eosinophil chemotaxis via inhibiting glycolysis-induced CCL26 expression in eosinophilic chronic rhinosinusitis with nasal polyps

Abstract Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is likely to relapse due to aberrant eosinophil infiltration. The deficiency of Vitamin D (VD) is associated with increased eosinophil infiltration in eosinophilic oesophagitis. However, the role of VD in eosinophilic CRSwNP (ECRS...

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Main Authors: Weiqiang Huang, Yana Zhang, Yue Li, Junming Ma, Xia Li, Yanjie Jiang, Jianqi Wang, Haotian Wu, Xiaohong Chen, Zizhen Huang, Xifu Wu, Xiaoping Lai, Donglin Li, Lihong Chang, Gehua Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
Eosinophilic chronic rhinosinusitis with nasal polyps
Eosinophil chemotaxis
Vitamin D
Glycolysis
Lactate
CCL26
Online Access:https://doi.org/10.1186/s12964-025-02078-2
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