Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, Iraq
Beta thalassemia is one of the most common hereditary diseases in the world caused by a deficiency of globin chains. Heart disease is one of the main complications of this disease as a result of excess iron deposition in the cardiac tissues. Total of 100 patients of 2-18 years diagnosed with ß-TM w...
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University of Baghdad, College of Science for Women
2024-06-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8352 |
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| author | Ahmed jaber ibrahim Arwa H. M. AL–Saeed |
| author_facet | Ahmed jaber ibrahim Arwa H. M. AL–Saeed |
| author_sort | Ahmed jaber ibrahim |
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Beta thalassemia is one of the most common hereditary diseases in the world caused by a deficiency of globin chains. Heart disease is one of the main complications of this disease as a result of excess iron deposition in the cardiac tissues. Total of 100 patients of 2-18 years diagnosed with ß-TM were employed in the current study and admitted to Thi-Qar Center of Hereditary Blood Diseases in Thi-Qar city, Iraq, and 80 healthy participants, matched by age, and geographical area were adopted as control group. The current study included evaluating of serum Troponin I (c.TnI), Creatine kinase-MB isoenzyme (CK-MB), Apelin, aspartate aminotransferase (AST), and Lactate Dehydrogenase enzyme (LDH) of studied groups. The finding revealed a significant increase (p<0.01) of c.TnI, CK-MB, AST, and LDH levels as well as a significant decrease (p<0.01) in apelin level in all patients with ß-TM compared to the control group. Pearson's correlation coefficient (r) was also found between the biochemical parameters studied for ß-TM patients with ferritin level, were found a significant correlation (p<0.01) between ferritin level with CK-MB, LDH, and AST levels while there was no significant correlation (P>0.01) through apelin and c.TnI levels. The finding showed a clinical predictor to damage cardiac tissues in the near term, which portends the use of more efficient treatment protocols to remove excess iron from ß-TM patients.
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| format | Article |
| id | doaj-art-bf518aa9eef04bd88def9b975ddea1ff |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-bf518aa9eef04bd88def9b975ddea1ff2025-08-20T03:39:04ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-06-0121610.21123/bsj.2023.8352Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, IraqAhmed jaber ibrahim0https://orcid.org/0000-0003-4245-7618Arwa H. M. AL–Saeed1https://orcid.org/0000-0002-6447-8965Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq.Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq. Beta thalassemia is one of the most common hereditary diseases in the world caused by a deficiency of globin chains. Heart disease is one of the main complications of this disease as a result of excess iron deposition in the cardiac tissues. Total of 100 patients of 2-18 years diagnosed with ß-TM were employed in the current study and admitted to Thi-Qar Center of Hereditary Blood Diseases in Thi-Qar city, Iraq, and 80 healthy participants, matched by age, and geographical area were adopted as control group. The current study included evaluating of serum Troponin I (c.TnI), Creatine kinase-MB isoenzyme (CK-MB), Apelin, aspartate aminotransferase (AST), and Lactate Dehydrogenase enzyme (LDH) of studied groups. The finding revealed a significant increase (p<0.01) of c.TnI, CK-MB, AST, and LDH levels as well as a significant decrease (p<0.01) in apelin level in all patients with ß-TM compared to the control group. Pearson's correlation coefficient (r) was also found between the biochemical parameters studied for ß-TM patients with ferritin level, were found a significant correlation (p<0.01) between ferritin level with CK-MB, LDH, and AST levels while there was no significant correlation (P>0.01) through apelin and c.TnI levels. The finding showed a clinical predictor to damage cardiac tissues in the near term, which portends the use of more efficient treatment protocols to remove excess iron from ß-TM patients. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8352c.TnI, CK-MB, β-thalassemia, Heart disorders, iron overload |
| spellingShingle | Ahmed jaber ibrahim Arwa H. M. AL–Saeed Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, Iraq مجلة بغداد للعلوم c.TnI, CK-MB, β-thalassemia, Heart disorders, iron overload |
| title | Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, Iraq |
| title_full | Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, Iraq |
| title_fullStr | Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, Iraq |
| title_full_unstemmed | Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, Iraq |
| title_short | Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, Iraq |
| title_sort | evaluation of some heart enzymes and iron levels in β thalassemia patients in thi qar city iraq |
| topic | c.TnI, CK-MB, β-thalassemia, Heart disorders, iron overload |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8352 |
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