Exploration of M2 macrophage-related biomarkers and a candidate drug for glioblastoma using high-dimensional weighted gene co-expression network analysis

Exploration of M2 macrophage-related biomarkers and a candidate drug for glioblastoma using high-dimensional weighted gene co-expression network analysis

BackgroundMacrophages exhibit diverse activation states. Notably, M2 macrophages, alternatively activated cells, are notably increased within glioblastoma (GBM). Herein, our current study aimed to identify gene biomarkers relevant to M2 macrophages using high-dimensional weighted gene co-expression...

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Bibliographic Details
Main Authors: Suyin Feng, Long Zhu, Jinyuan Gu, Kun Kou, Yongtai Liu, Guangmin Zhang, Hua Lu, Honglai Zhang, Runfeng Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
tumor-associated macrophages
M2 macrophages
glioblastoma
high-dimensional weighted gene co-expression network analysis
thalidomide
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1587258/full
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