Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repair
Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by complex tissue interactions, featuring cartilage degradation, synovitis, and aberrant subchondral bone remodeling. Current therapies often fail to halt disease progression and typically lack comprehensive strategies targ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1629608/full |
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| author | Yingguang Jiao Yingguang Jiao Shanyu Lu Shanyu Lu Jianwei Zhang Junping Zhen Junping Zhen |
| author_facet | Yingguang Jiao Yingguang Jiao Shanyu Lu Shanyu Lu Jianwei Zhang Junping Zhen Junping Zhen |
| author_sort | Yingguang Jiao |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by complex tissue interactions, featuring cartilage degradation, synovitis, and aberrant subchondral bone remodeling. Current therapies often fail to halt disease progression and typically lack comprehensive strategies targeting OA pathogenesis. Osteochondral organoids have recently emerged as innovative 3D biological models for investigating OA mechanisms and developing personalized therapies. These models recapitulate dynamic cell-cell and cell-matrix interactions within the articular microenvironment. This review evaluates progress in applying osteochondral organoids to osteoarthritis, focusing on their fabrication strategies, applications, and key challenges. It emphasizes their role in osteoarthritis modeling, drug screening, and cartilage regeneration, while exploring future directions for their development. Despite these advances, clinical translation of osteochondral organoids faces significant challenges, including standardization, vascularization, and immunomodulation. Future integration with organ-on-chip platforms, multi-omics, and AI promises to create more precise OA research models. Such integration will bridge the gap between bench research and clinical practice. |
| format | Article |
| id | doaj-art-bf4fef12333441cdb5bf9eb1a23cbe69 |
| institution | DOAJ |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-bf4fef12333441cdb5bf9eb1a23cbe692025-08-20T02:50:33ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-07-011310.3389/fbioe.2025.16296081629608Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repairYingguang Jiao0Yingguang Jiao1Shanyu Lu2Shanyu Lu3Jianwei Zhang4Junping Zhen5Junping Zhen6College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaCollege of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaMolecular Imaging Laboratory, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaOsteoarthritis (OA) is a prevalent degenerative joint disorder characterized by complex tissue interactions, featuring cartilage degradation, synovitis, and aberrant subchondral bone remodeling. Current therapies often fail to halt disease progression and typically lack comprehensive strategies targeting OA pathogenesis. Osteochondral organoids have recently emerged as innovative 3D biological models for investigating OA mechanisms and developing personalized therapies. These models recapitulate dynamic cell-cell and cell-matrix interactions within the articular microenvironment. This review evaluates progress in applying osteochondral organoids to osteoarthritis, focusing on their fabrication strategies, applications, and key challenges. It emphasizes their role in osteoarthritis modeling, drug screening, and cartilage regeneration, while exploring future directions for their development. Despite these advances, clinical translation of osteochondral organoids faces significant challenges, including standardization, vascularization, and immunomodulation. Future integration with organ-on-chip platforms, multi-omics, and AI promises to create more precise OA research models. Such integration will bridge the gap between bench research and clinical practice.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1629608/fullosteoarthritisosteochondral organoidstissue engineeringdrug screening3D bioprintingpathomimetic modeling |
| spellingShingle | Yingguang Jiao Yingguang Jiao Shanyu Lu Shanyu Lu Jianwei Zhang Junping Zhen Junping Zhen Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repair Frontiers in Bioengineering and Biotechnology osteoarthritis osteochondral organoids tissue engineering drug screening 3D bioprinting pathomimetic modeling |
| title | Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repair |
| title_full | Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repair |
| title_fullStr | Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repair |
| title_full_unstemmed | Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repair |
| title_short | Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repair |
| title_sort | applications in osteochondral organoids for osteoarthritis research from pathomimetic modeling to tissue engineering repair |
| topic | osteoarthritis osteochondral organoids tissue engineering drug screening 3D bioprinting pathomimetic modeling |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1629608/full |
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