Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds
The essential oil of celery ( Apium graveolens ) is characterized by exceptionally high content of alkylphthalides. The mentioned compounds exhibit a number of biological effects (including hypotensive, lipid-lowering, neuroprotective, and cytotoxic) and are also responsible for distinctive aroma of...
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2021-06-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://journal.pan.olsztyn.pl/Optimization-of-Distillation-Conditions-for-Improved-Recovery-of-Phthalides-from,137612,0,2.html |
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| author | Adam Kokotkiewicz Anna Badura Żaneta Tabaczyńska Andżelika Lorenc Adam Buciński Maria Luczkiewicz |
| author_facet | Adam Kokotkiewicz Anna Badura Żaneta Tabaczyńska Andżelika Lorenc Adam Buciński Maria Luczkiewicz |
| author_sort | Adam Kokotkiewicz |
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| description | The essential oil of celery ( Apium graveolens ) is characterized by exceptionally high content of alkylphthalides. The mentioned compounds exhibit a number of biological effects (including hypotensive, lipid-lowering, neuroprotective, and cytotoxic) and are also responsible for distinctive aroma of the plant. In the current work, parameters of conventional hydrodistillation (HD) and simultaneous distillation-extraction (SDE) were optimized to obtain phthalide-enriched fractions of celery seeds. A positive correlation was shown between hydrodistillation time and improved essential oil and phthalide yields. The 6-h HD of comminuted seeds yielded essential oil (2.9%) with a higher total phthalide content (51%), as compared to the samples collected after 1.5-3.0 h, which gave 2.4-2.7% of oil containing 24.6-39.2% of total phthalides. The oil contained sedanenolide (36.7%), 3- n -butylphthalide (13.1%), and sedanolide (1.1%). A further increase in the total phthalide content was achieved by omitting the size reduction step prior to hydrodistillation (68.8%) and utilization of the salting-out effect (84.3%). Enzyme pretreatment had a negligible effect on essential oil and phthalide yields. The change of distillation mode from HD to SDE significantly increased the oil yield of whole seeds (from 2.8 to 5.8% for 6 h processing) while maintaining its high phthalide content (62.5%), which translated to an increase in the total phthalide yield from 19.4 to 36.0 g/kg. |
| format | Article |
| id | doaj-art-bf4d66929cf746149d05618c86c1801e |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-bf4d66929cf746149d05618c86c1801e2025-02-02T20:34:22ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072021-06-0171219721010.31883/pjfns/137612137612Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) SeedsAdam Kokotkiewicz0Anna Badura1Żaneta Tabaczyńska2Andżelika Lorenc3Adam Buciński4Maria Luczkiewicz5Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, PolandDepartment of Biopharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, PolandDepartment of Biopharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, PolandDepartment of Biopharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, PolandDepartment of Biopharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, PolandDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, PolandThe essential oil of celery ( Apium graveolens ) is characterized by exceptionally high content of alkylphthalides. The mentioned compounds exhibit a number of biological effects (including hypotensive, lipid-lowering, neuroprotective, and cytotoxic) and are also responsible for distinctive aroma of the plant. In the current work, parameters of conventional hydrodistillation (HD) and simultaneous distillation-extraction (SDE) were optimized to obtain phthalide-enriched fractions of celery seeds. A positive correlation was shown between hydrodistillation time and improved essential oil and phthalide yields. The 6-h HD of comminuted seeds yielded essential oil (2.9%) with a higher total phthalide content (51%), as compared to the samples collected after 1.5-3.0 h, which gave 2.4-2.7% of oil containing 24.6-39.2% of total phthalides. The oil contained sedanenolide (36.7%), 3- n -butylphthalide (13.1%), and sedanolide (1.1%). A further increase in the total phthalide content was achieved by omitting the size reduction step prior to hydrodistillation (68.8%) and utilization of the salting-out effect (84.3%). Enzyme pretreatment had a negligible effect on essential oil and phthalide yields. The change of distillation mode from HD to SDE significantly increased the oil yield of whole seeds (from 2.8 to 5.8% for 6 h processing) while maintaining its high phthalide content (62.5%), which translated to an increase in the total phthalide yield from 19.4 to 36.0 g/kg.http://journal.pan.olsztyn.pl/Optimization-of-Distillation-Conditions-for-Improved-Recovery-of-Phthalides-from,137612,0,2.htmlalkylphthalidesenzyme pretreatmenthydrodistillationsalting-out effectsimultaneous distillation-extractionsize reduction |
| spellingShingle | Adam Kokotkiewicz Anna Badura Żaneta Tabaczyńska Andżelika Lorenc Adam Buciński Maria Luczkiewicz Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds Polish Journal of Food and Nutrition Sciences alkylphthalides enzyme pretreatment hydrodistillation salting-out effect simultaneous distillation-extraction size reduction |
| title | Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds |
| title_full | Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds |
| title_fullStr | Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds |
| title_full_unstemmed | Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds |
| title_short | Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds |
| title_sort | optimization of distillation conditions for improved recovery of phthalides from celery apium graveolens l seeds |
| topic | alkylphthalides enzyme pretreatment hydrodistillation salting-out effect simultaneous distillation-extraction size reduction |
| url | http://journal.pan.olsztyn.pl/Optimization-of-Distillation-Conditions-for-Improved-Recovery-of-Phthalides-from,137612,0,2.html |
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