Neuroprotective potential of gliflozins
Gliflozins are a relatively new class of oral antihyperglycemic drugs that are increasingly being introduced into routine practice in the treatment of patients with type 2 diabetes mellitus (DM2). The hypoglycemic effect of gliflozins is associated with the stimulation of glucosuria, however, in add...
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Endocrinology Research Centre
2023-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/13085 |
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| author | A. S. Kokin L. A. Suplotova |
| author_facet | A. S. Kokin L. A. Suplotova |
| author_sort | A. S. Kokin |
| collection | DOAJ |
| description | Gliflozins are a relatively new class of oral antihyperglycemic drugs that are increasingly being introduced into routine practice in the treatment of patients with type 2 diabetes mellitus (DM2). The hypoglycemic effect of gliflozins is associated with the stimulation of glucosuria, however, in addition to a pronounced hypoglycemic effect and high safety, these drugs also have many pleiotropic properties, due to the presence of many direct and indirect points of application. The purpose of this paper is to provide an overview of the currently best studied neuroprotective effects of this class of drugs. As materials in the course of the work, studies of foreign colleagues published in the period 2008–2022 were used. Analysis of the works showed that the neuroprotective effect of gliflozins is associated with many different mechanisms. Thus, gliflozins realize an anti-inflammatory effect by activating the M2 subpopulation of macrophages, reducing pro-inflammatory neurotransmitters (related primarily to the inflammasome). In addition, by reducing the activity of the mTOR signaling pathway, the drugs reduce the amount of beta-amyloid and improve neurotransmission. A group of works also showed the antiacetylcholinesterase effect of gliflozins, not to mention the decrease in the intensity of non-enzymatic protein glycation and insulin resistance. All of the above mechanisms provide an anti-inflammatory, anti-atherogenic effect, improve cognitive abilities in patients, reduce the frequency of hemorrhagic stroke, and can also potentially improve prognosis in patients with Alzheimer’s disease (AD). The effects described above were obtained during preclinical trials and many experimental studies, and some effects have already demonstrated their consistency in prospective clinical trials. However, the data obtained are still insufficient to form clear indications for this class of drugs in neurology, so the topic requires further study and clinical trials. |
| format | Article |
| id | doaj-art-bf4cd684a9c042a885486be2632413e6 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-bf4cd684a9c042a885486be2632413e62025-08-20T03:09:03ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782023-12-0126659660210.14341/DM1308511060Neuroprotective potential of gliflozinsA. S. Kokin0L. A. Suplotova1Tyumen State Medical UniversityTyumen State Medical UniversityGliflozins are a relatively new class of oral antihyperglycemic drugs that are increasingly being introduced into routine practice in the treatment of patients with type 2 diabetes mellitus (DM2). The hypoglycemic effect of gliflozins is associated with the stimulation of glucosuria, however, in addition to a pronounced hypoglycemic effect and high safety, these drugs also have many pleiotropic properties, due to the presence of many direct and indirect points of application. The purpose of this paper is to provide an overview of the currently best studied neuroprotective effects of this class of drugs. As materials in the course of the work, studies of foreign colleagues published in the period 2008–2022 were used. Analysis of the works showed that the neuroprotective effect of gliflozins is associated with many different mechanisms. Thus, gliflozins realize an anti-inflammatory effect by activating the M2 subpopulation of macrophages, reducing pro-inflammatory neurotransmitters (related primarily to the inflammasome). In addition, by reducing the activity of the mTOR signaling pathway, the drugs reduce the amount of beta-amyloid and improve neurotransmission. A group of works also showed the antiacetylcholinesterase effect of gliflozins, not to mention the decrease in the intensity of non-enzymatic protein glycation and insulin resistance. All of the above mechanisms provide an anti-inflammatory, anti-atherogenic effect, improve cognitive abilities in patients, reduce the frequency of hemorrhagic stroke, and can also potentially improve prognosis in patients with Alzheimer’s disease (AD). The effects described above were obtained during preclinical trials and many experimental studies, and some effects have already demonstrated their consistency in prospective clinical trials. However, the data obtained are still insufficient to form clear indications for this class of drugs in neurology, so the topic requires further study and clinical trials.https://www.dia-endojournals.ru/jour/article/view/13085neuroprotectionalzheimer’s diseasegliflozinssodium-glucose cotransporter-2 inhibitorsdiabetes mellitushemorrhagic strokecognitive impairment |
| spellingShingle | A. S. Kokin L. A. Suplotova Neuroprotective potential of gliflozins Сахарный диабет neuroprotection alzheimer’s disease gliflozins sodium-glucose cotransporter-2 inhibitors diabetes mellitus hemorrhagic stroke cognitive impairment |
| title | Neuroprotective potential of gliflozins |
| title_full | Neuroprotective potential of gliflozins |
| title_fullStr | Neuroprotective potential of gliflozins |
| title_full_unstemmed | Neuroprotective potential of gliflozins |
| title_short | Neuroprotective potential of gliflozins |
| title_sort | neuroprotective potential of gliflozins |
| topic | neuroprotection alzheimer’s disease gliflozins sodium-glucose cotransporter-2 inhibitors diabetes mellitus hemorrhagic stroke cognitive impairment |
| url | https://www.dia-endojournals.ru/jour/article/view/13085 |
| work_keys_str_mv | AT askokin neuroprotectivepotentialofgliflozins AT lasuplotova neuroprotectivepotentialofgliflozins |