Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective
The incidence of cerebrovascular disease is highest in the elderly population. However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. Ischemic changes in the commonly used young animal stroke models do not reflect the molecular c...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/857484 |
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| _version_ | 1832545810193055744 |
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| author | Mario Di Napoli Imtiaz M. Shah |
| author_facet | Mario Di Napoli Imtiaz M. Shah |
| author_sort | Mario Di Napoli |
| collection | DOAJ |
| description | The incidence of cerebrovascular disease is highest in the elderly population. However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. Ischemic changes in the commonly used young animal stroke models do not reflect the molecular changes associated with the aged brain. Neuroinflammation and oxidative stress are important pathogenic processes occurring during the acute phase of cerebral ischemia. Free radical generation is also implicated in the aging process, and the combination of these effects in elderly stroke patients could explain the higher risk of morbidity and mortality. A better understanding of stroke pathophysiology in the elderly patient would assist in the development of new therapeutic strategies for this vulnerable age group. With the increasing use of reperfusion therapies, inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents. This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective. |
| format | Article |
| id | doaj-art-bf4ca0c025b14a228deaf59a2bdea380 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-bf4ca0c025b14a228deaf59a2bdea3802025-02-03T07:24:42ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/857484857484Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine PerspectiveMario Di Napoli0Imtiaz M. Shah1Neurological Service, San Camillo de'Lellis General Hospital, 02100 Rieti, ItalyStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland G4 0RE, UKThe incidence of cerebrovascular disease is highest in the elderly population. However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. Ischemic changes in the commonly used young animal stroke models do not reflect the molecular changes associated with the aged brain. Neuroinflammation and oxidative stress are important pathogenic processes occurring during the acute phase of cerebral ischemia. Free radical generation is also implicated in the aging process, and the combination of these effects in elderly stroke patients could explain the higher risk of morbidity and mortality. A better understanding of stroke pathophysiology in the elderly patient would assist in the development of new therapeutic strategies for this vulnerable age group. With the increasing use of reperfusion therapies, inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents. This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective.http://dx.doi.org/10.4061/2011/857484 |
| spellingShingle | Mario Di Napoli Imtiaz M. Shah Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective Journal of Aging Research |
| title | Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective |
| title_full | Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective |
| title_fullStr | Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective |
| title_full_unstemmed | Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective |
| title_short | Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective |
| title_sort | neuroinflammation and cerebrovascular disease in old age a translational medicine perspective |
| url | http://dx.doi.org/10.4061/2011/857484 |
| work_keys_str_mv | AT mariodinapoli neuroinflammationandcerebrovasculardiseaseinoldageatranslationalmedicineperspective AT imtiazmshah neuroinflammationandcerebrovasculardiseaseinoldageatranslationalmedicineperspective |