Trajectories of HbA1c levels in children and youth with type 1 diabetes.
<h4>Purpose</h4>To illustrate the distribution of Hemoglobin A1c (HbA1c) levels according to age and gender among children, adolescents and youth with type 1 diabetes (T1DM).<h4>Methods</h4>Consecutive HbA1c measurements of 349 patients, aged 2 to 30 years with T1DM were obta...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0109109 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850191374986510336 |
|---|---|
| author | Orit Pinhas-Hamiel Uri Hamiel Valentina Boyko Chana Graph-Barel Brian Reichman Liat Lerner-Geva |
| author_facet | Orit Pinhas-Hamiel Uri Hamiel Valentina Boyko Chana Graph-Barel Brian Reichman Liat Lerner-Geva |
| author_sort | Orit Pinhas-Hamiel |
| collection | DOAJ |
| description | <h4>Purpose</h4>To illustrate the distribution of Hemoglobin A1c (HbA1c) levels according to age and gender among children, adolescents and youth with type 1 diabetes (T1DM).<h4>Methods</h4>Consecutive HbA1c measurements of 349 patients, aged 2 to 30 years with T1DM were obtained from 1995 through 2010. Measurement from patients diagnosed with celiac disease (n = 20), eating disorders (n = 41) and hemoglobinopathy (n = 1) were excluded. The study sample comprised 4815 measurements of HbA1c from 287 patients. Regression percentiles of HbA1c were calculated as a function of age and gender by the quantile regression method using the SAS procedure QUANTREG.<h4>Results</h4>Crude percentiles of HbA1c as a function of age and gender, and the modeled curves produced using quantile regression showed good concordance. The curves show a decline in HbA1c levels from age 2 to 4 years at each percentile. Thereafter, there is a gradual increase during the prepubertal years with a peak at ages 12 to 14 years. HbA1c levels subsequently decline to the lowest values in the third decade. Curves of females and males followed closely, with females having HbA1c levels about 0.1% (1.1 mmol/mol) higher in the 25th 50th and 75th percentiles.<h4>Conclusion</h4>We constructed age-specific distribution curves for HbA1c levels for patients with T1DM. These percentiles may be used to demonstrate the individual patient's measurements longitudinally compared with age-matched patients. |
| format | Article |
| id | doaj-art-bf46d2b1824c4e849e7d881d6f55fb68 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-bf46d2b1824c4e849e7d881d6f55fb682025-08-20T02:14:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e10910910.1371/journal.pone.0109109Trajectories of HbA1c levels in children and youth with type 1 diabetes.Orit Pinhas-HamielUri HamielValentina BoykoChana Graph-BarelBrian ReichmanLiat Lerner-Geva<h4>Purpose</h4>To illustrate the distribution of Hemoglobin A1c (HbA1c) levels according to age and gender among children, adolescents and youth with type 1 diabetes (T1DM).<h4>Methods</h4>Consecutive HbA1c measurements of 349 patients, aged 2 to 30 years with T1DM were obtained from 1995 through 2010. Measurement from patients diagnosed with celiac disease (n = 20), eating disorders (n = 41) and hemoglobinopathy (n = 1) were excluded. The study sample comprised 4815 measurements of HbA1c from 287 patients. Regression percentiles of HbA1c were calculated as a function of age and gender by the quantile regression method using the SAS procedure QUANTREG.<h4>Results</h4>Crude percentiles of HbA1c as a function of age and gender, and the modeled curves produced using quantile regression showed good concordance. The curves show a decline in HbA1c levels from age 2 to 4 years at each percentile. Thereafter, there is a gradual increase during the prepubertal years with a peak at ages 12 to 14 years. HbA1c levels subsequently decline to the lowest values in the third decade. Curves of females and males followed closely, with females having HbA1c levels about 0.1% (1.1 mmol/mol) higher in the 25th 50th and 75th percentiles.<h4>Conclusion</h4>We constructed age-specific distribution curves for HbA1c levels for patients with T1DM. These percentiles may be used to demonstrate the individual patient's measurements longitudinally compared with age-matched patients.https://doi.org/10.1371/journal.pone.0109109 |
| spellingShingle | Orit Pinhas-Hamiel Uri Hamiel Valentina Boyko Chana Graph-Barel Brian Reichman Liat Lerner-Geva Trajectories of HbA1c levels in children and youth with type 1 diabetes. PLoS ONE |
| title | Trajectories of HbA1c levels in children and youth with type 1 diabetes. |
| title_full | Trajectories of HbA1c levels in children and youth with type 1 diabetes. |
| title_fullStr | Trajectories of HbA1c levels in children and youth with type 1 diabetes. |
| title_full_unstemmed | Trajectories of HbA1c levels in children and youth with type 1 diabetes. |
| title_short | Trajectories of HbA1c levels in children and youth with type 1 diabetes. |
| title_sort | trajectories of hba1c levels in children and youth with type 1 diabetes |
| url | https://doi.org/10.1371/journal.pone.0109109 |
| work_keys_str_mv | AT oritpinhashamiel trajectoriesofhba1clevelsinchildrenandyouthwithtype1diabetes AT urihamiel trajectoriesofhba1clevelsinchildrenandyouthwithtype1diabetes AT valentinaboyko trajectoriesofhba1clevelsinchildrenandyouthwithtype1diabetes AT chanagraphbarel trajectoriesofhba1clevelsinchildrenandyouthwithtype1diabetes AT brianreichman trajectoriesofhba1clevelsinchildrenandyouthwithtype1diabetes AT liatlernergeva trajectoriesofhba1clevelsinchildrenandyouthwithtype1diabetes |