Glances in Immunology of HIV and HCV Infection
Since the identification of HIV and HCV much progress has been made in the understanding of their life cycle and interaction with the host immune system. Despite these viruses markedly differ in their virological properties and in their pathogenesis, they share many common features in their immune e...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2012/434036 |
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| author | Maria Giovanna Quaranta Benedetta Mattioli Stefano Vella |
| author_facet | Maria Giovanna Quaranta Benedetta Mattioli Stefano Vella |
| author_sort | Maria Giovanna Quaranta |
| collection | DOAJ |
| description | Since the identification of HIV and HCV much progress has been made in the understanding of their life cycle and interaction with the host immune system. Despite these viruses markedly differ in their virological properties and in their pathogenesis, they share many common features in their immune escape and survival strategy. Both viruses have developed sophisticated ways to subvert and antagonize host innate and adaptive immune responses. In the last years, much effort has been done in the study of the AIDS pathogenesis and in the development of efficient treatment strategies, and a fatal infection has been transformed in a potentially chronic pathology. Much of this knowledge is now being transferred in the HCV research field, especially in the development of new drugs, although a big difference still remains between the outcome of the two infections, being HCV eradicable after treatment, whereas HIV eradication remains at present unachievable due to the establishment of reservoirs. In this review, we present current knowledge on innate and adaptive immune recognition and activation during HIV and HCV mono-infections and evasion strategies. We also discuss the genetic associations between components of the immune system, the course of infection, and the outcome of the therapies. |
| format | Article |
| id | doaj-art-bf45d9af97a649989192ffb6985d4c15 |
| institution | DOAJ |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-bf45d9af97a649989192ffb6985d4c152025-08-20T03:23:07ZengWileyAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/434036434036Glances in Immunology of HIV and HCV InfectionMaria Giovanna Quaranta0Benedetta Mattioli1Stefano Vella2Department of Therapeutics and Medicines Evaluation, Istituto Superiore di Sanita', 00161 Rome, ItalyDepartment of Therapeutics and Medicines Evaluation, Istituto Superiore di Sanita', 00161 Rome, ItalyDepartment of Therapeutics and Medicines Evaluation, Istituto Superiore di Sanita', 00161 Rome, ItalySince the identification of HIV and HCV much progress has been made in the understanding of their life cycle and interaction with the host immune system. Despite these viruses markedly differ in their virological properties and in their pathogenesis, they share many common features in their immune escape and survival strategy. Both viruses have developed sophisticated ways to subvert and antagonize host innate and adaptive immune responses. In the last years, much effort has been done in the study of the AIDS pathogenesis and in the development of efficient treatment strategies, and a fatal infection has been transformed in a potentially chronic pathology. Much of this knowledge is now being transferred in the HCV research field, especially in the development of new drugs, although a big difference still remains between the outcome of the two infections, being HCV eradicable after treatment, whereas HIV eradication remains at present unachievable due to the establishment of reservoirs. In this review, we present current knowledge on innate and adaptive immune recognition and activation during HIV and HCV mono-infections and evasion strategies. We also discuss the genetic associations between components of the immune system, the course of infection, and the outcome of the therapies.http://dx.doi.org/10.1155/2012/434036 |
| spellingShingle | Maria Giovanna Quaranta Benedetta Mattioli Stefano Vella Glances in Immunology of HIV and HCV Infection Advances in Virology |
| title | Glances in Immunology of HIV and HCV Infection |
| title_full | Glances in Immunology of HIV and HCV Infection |
| title_fullStr | Glances in Immunology of HIV and HCV Infection |
| title_full_unstemmed | Glances in Immunology of HIV and HCV Infection |
| title_short | Glances in Immunology of HIV and HCV Infection |
| title_sort | glances in immunology of hiv and hcv infection |
| url | http://dx.doi.org/10.1155/2012/434036 |
| work_keys_str_mv | AT mariagiovannaquaranta glancesinimmunologyofhivandhcvinfection AT benedettamattioli glancesinimmunologyofhivandhcvinfection AT stefanovella glancesinimmunologyofhivandhcvinfection |