Association between dietary inflammatory and antioxidant potential and systemic inflammatory and oxidative status with the risk and severity of coronary artery disease.
<h4>Background and aims</h4>Unhealthy diets have pro-inflammatory properties that have been shown to contribute to coronary artery disease (CAD). The dietary inflammatory index (DII®) and the dietary antioxidant quality score (DAQS) quantify the anti-/pro-inflammatory and antioxidant pot...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0325716 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <h4>Background and aims</h4>Unhealthy diets have pro-inflammatory properties that have been shown to contribute to coronary artery disease (CAD). The dietary inflammatory index (DII®) and the dietary antioxidant quality score (DAQS) quantify the anti-/pro-inflammatory and antioxidant potential of a diet. This study aims to investigate the association between the energy-adjusted DII (E-DIITM), DAQS, oxidant/anti-oxidant biomarkers, and CAD risk and severity.<h4>Methods and results</h4>This cross-sectional study investigated 158 participants for the presence and severity of CAD based on coronary angiography. E-DII and DAQS scores, malondialdehyde (MDA), total oxidant status (TOS), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC) and conventional cardiometabolic risk factors were assessed. The triglyceride-glucose (TyG) index and mean arterial pressure (MAP) were also calculated. No association was observed between the E-DII or DAQS and the presence or severity of CAD. Based on the final regression models, age (adjusted odds ratio (AOR) =1.07, P = 0.002), male sex (AOR = 5.02, P < 0.001), MAP (AOR = 1.03, P = 0.03), HDL-C (AOR = 1.04, P = 0.06) and hs-CRP (AOR = 1.06, P = 0.045) as well as TOS (AOR = 1.16, P = 0.03) and TAC (AOR = 1.51, P = 0.07) increased and GPX activity (AOR = 0.51, P = 0.07) decreased the odds of having CAD. Male sex (adjusted β (Aβ) =22.04, P < 0.001), age (Aβ = 0.87, P = 0.003), hs-CRP (Aβ = 0.72, P = 0.045) and TOS (Aβ = 2.75, P = 0.003) were associated with higher Gensini scores. Higher GPX activity (Aβ = -10.95, P = 0.03) was associated with lower Gensini scores.<h4>Conclusion</h4>Biomarkers of oxidative stress, including TOS, TAC, and GPX activity, were associated with the presence, extent or severity of coronary atherosclerosis while no associations were observed for E-DII and DAQS scores. |
|---|---|
| ISSN: | 1932-6203 |