Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review
The intricacies of skin conditions and the limitation of traditional therapeutic strategies make dermal treatment fairly difficult. Recent advancements in nanotechnology field have demonstrated promise in dealing such problems, specifically, the application of biogenic synthesized metallic nano-bio-...
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Elsevier
2025-05-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625002553 |
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| author | Min He Jun Hu Jiaxin Deng Xueqiang Chen Anil Kumar Singh Pooja V. Nagime Himanshu Paliwal Sudarshan Singh Opeyemi Joshua Olatunji |
| author_facet | Min He Jun Hu Jiaxin Deng Xueqiang Chen Anil Kumar Singh Pooja V. Nagime Himanshu Paliwal Sudarshan Singh Opeyemi Joshua Olatunji |
| author_sort | Min He |
| collection | DOAJ |
| description | The intricacies of skin conditions and the limitation of traditional therapeutic strategies make dermal treatment fairly difficult. Recent advancements in nanotechnology field have demonstrated promise in dealing such problems, specifically, the application of biogenic synthesized metallic nano-bio-composites. This review is focused upon synthesis, characterization, and transformation of metallic nanoparticles (NPs) into polymeric composite for the management of dermal complications, with emphasis on how they can enhance drug delivery, promote wound healing, and mitigate inflammation. By employing bioactive-rich substances from plants, the phyto-mediated approach confirms biocompatibility and reduced cytotoxic potential metallic NPs with 99.9 % of antibacterial activity. Such nanocomposites furnish augmented physicochemical properties, including targeted therapeutic action, regulated release, and improved stability, upon combination with polymers and metallic NPs, such as silver nanoparticles (AgNPs). The mechanism responsible for their activity in the treatment of dermal complication due to their excellent antibacterial, antioxidant, and anti-inflammatory activity with a focus on wound healing application have been presented in the paper. Additionally, the review encourages the interdisciplinary strategies to optimize their clinical applicability, while evaluating their current limitations and future research directions. Thus, the review highlights the potential of phyto-mediated polymeric incorporated metallic nano-bio-composites as revolutionizing solution for the management of dermal complications, paving the way for the next-generation therapeutic approaches. |
| format | Article |
| id | doaj-art-bf3e7c4010db4218a62a0c17a7521d60 |
| institution | OA Journals |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-bf3e7c4010db4218a62a0c17a7521d602025-08-20T02:33:12ZengElsevierResults in Chemistry2211-71562025-05-011510227210.1016/j.rechem.2025.102272Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A reviewMin He0Jun Hu1Jiaxin Deng2Xueqiang Chen3Anil Kumar Singh4Pooja V. Nagime5Himanshu Paliwal6Sudarshan Singh7Opeyemi Joshua Olatunji8Second People's Hospital of Wuhu City, Anhui 241100, ChinaSecond People's Hospital of Wuhu City, Anhui 241100, ChinaHuzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Huzhou City, Zhejiang, 313000, ChinaHuzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Huzhou City, Zhejiang, 313000, ChinaUnited Institute of Pharmacy, Prayagraj, Uttar Pradesh 211010, IndiaCentre of Excellence in Innovative Biotechnology for Sustainable Utilization of Bioresources, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand; Corresponding authors.Marwadi University Research Center, Faculty of Pharmacy, Marwadi University, Rajkot 360003, Gujarat, India; Corresponding authors.Office of Research Administration, Chaing Mai University, Chiang Mai 50200, Thailand; Faculty of Pharmacy, Chaing Mai University, Chiang Mai 50200, Thailand; Corresponding authors.African Genome Center, Mohammed VI Polytechnic University, Benguerir, MoroccoThe intricacies of skin conditions and the limitation of traditional therapeutic strategies make dermal treatment fairly difficult. Recent advancements in nanotechnology field have demonstrated promise in dealing such problems, specifically, the application of biogenic synthesized metallic nano-bio-composites. This review is focused upon synthesis, characterization, and transformation of metallic nanoparticles (NPs) into polymeric composite for the management of dermal complications, with emphasis on how they can enhance drug delivery, promote wound healing, and mitigate inflammation. By employing bioactive-rich substances from plants, the phyto-mediated approach confirms biocompatibility and reduced cytotoxic potential metallic NPs with 99.9 % of antibacterial activity. Such nanocomposites furnish augmented physicochemical properties, including targeted therapeutic action, regulated release, and improved stability, upon combination with polymers and metallic NPs, such as silver nanoparticles (AgNPs). The mechanism responsible for their activity in the treatment of dermal complication due to their excellent antibacterial, antioxidant, and anti-inflammatory activity with a focus on wound healing application have been presented in the paper. Additionally, the review encourages the interdisciplinary strategies to optimize their clinical applicability, while evaluating their current limitations and future research directions. Thus, the review highlights the potential of phyto-mediated polymeric incorporated metallic nano-bio-composites as revolutionizing solution for the management of dermal complications, paving the way for the next-generation therapeutic approaches.http://www.sciencedirect.com/science/article/pii/S2211715625002553Dermal complicationsMetallic nanoparticles. Phyto-mediated polymersSilver nanoparticlesWound healing |
| spellingShingle | Min He Jun Hu Jiaxin Deng Xueqiang Chen Anil Kumar Singh Pooja V. Nagime Himanshu Paliwal Sudarshan Singh Opeyemi Joshua Olatunji Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review Results in Chemistry Dermal complications Metallic nanoparticles. Phyto-mediated polymers Silver nanoparticles Wound healing |
| title | Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review |
| title_full | Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review |
| title_fullStr | Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review |
| title_full_unstemmed | Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review |
| title_short | Phyto-mediated polymeric incorporated silver nano-bio-composite for improved dermal complication management: A review |
| title_sort | phyto mediated polymeric incorporated silver nano bio composite for improved dermal complication management a review |
| topic | Dermal complications Metallic nanoparticles. Phyto-mediated polymers Silver nanoparticles Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625002553 |
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