A lethal DENV-2 wild-type mouse model for mutagenesis investigations

A lethal DENV-2 wild-type mouse model for mutagenesis investigations

Abstract Background Effective mouse models for testing antiviral medications should be both cost-effective and require minimal labor. Immunodeficient mouse models, such as AG129, are commonly used in dengue virus (DENV) research; however, their high import and maintenance costs make them relatively...

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Bibliographic Details
Main Authors: Zhiran Qin, Xiaoting Xie, Hua Ye, Hao Wu, Zhuoyun Li, Jingshu Li, Xiaoen He, Zuxin Liang, Xuling Liu, Li Zhu, Qinghua Wu, Weiwei Xiao, Kefeng Wu, Chengsong Wan, Bao Zhang, Zhaohui Sun, Jianhai Yu, Chenguang Shen, Linzhong Yu, Wei Zhao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biology
Subjects:
Dengue virus
Type I interferon
Antibody blockade
Mouse model
Viral mutation
Online Access:https://doi.org/10.1186/s12915-025-02332-6
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