The gestational age‐specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort study
Abstract Introduction Accumulating studies have suggested singletons born after frozen embryo transfer (FET) were higher than those born after fresh embryo transfer (Fre‐ET). However, fewer studies had investigated the gestational age‐specific between‐group difference in birthweight. This study aime...
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Wiley
2023-03-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.14503 |
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| author | Qiaoqiao Ding Yuhuan Wang Lu Suo Yue Niu Dingying Zhao Yunhai Yu Daimin Wei |
| author_facet | Qiaoqiao Ding Yuhuan Wang Lu Suo Yue Niu Dingying Zhao Yunhai Yu Daimin Wei |
| author_sort | Qiaoqiao Ding |
| collection | DOAJ |
| description | Abstract Introduction Accumulating studies have suggested singletons born after frozen embryo transfer (FET) were higher than those born after fresh embryo transfer (Fre‐ET). However, fewer studies had investigated the gestational age‐specific between‐group difference in birthweight. This study aimed to investigate the gestational week‐specific difference in singleton birthweight after FET vs Fre‐ET and explore potential factors that impact the difference. Material and methods In this retrospective cohort study, a total of 25 863 singletons were included. Multivariable linear regression and logistic regression were used to evaluate the between‐group differences in mean birthweight and the incidences of large for gestational age (LGA) and small for gestational age (SGA), respectively. Results Multivariable regression analyses showed a statistically significant interaction between types of embryo transfer (ie FET vs Fre‐ET) and the gestational week on mean birthweight (P < 0.001) and on the risks of large for gestational age (P = 0.001) and small for gestational age (P < 0.001). When stratified by gestational week, the differences in mean birthweight and the risks of LGA and SGA were only observed in singletons born at 37 gestational weeks or later. After adjusting for confounders, full‐term but not preterm singletons born after FET had a higher birthweight (3497.58 ± 439.73 g vs 3445.67 ± 450.24 g; adjusted mean difference 58.35 g; 95% confidence interval [CI] 38.72–77.98 g), a higher risk of LGA (24.3% vs 21.1%; adjusted odds ratio [OR] 1.28, 95% CI 1.15–1.42) and a lower risk of SGA (3.1% vs 4.8%; adjusted OR 0.61, 95% CI 0.53–0.70) compared with those born after Fre‐ET. Conclusions The differences in birthweight between FET and Fre‐ET were observed in full‐term singletons but not preterm singletons. |
| format | Article |
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| institution | OA Journals |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Wiley |
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| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-bf3bfda229f0446fbb4657aabe94a4802025-08-20T02:36:42ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122023-03-01102332333310.1111/aogs.14503The gestational age‐specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort studyQiaoqiao Ding0Yuhuan Wang1Lu Suo2Yue Niu3Dingying Zhao4Yunhai Yu5Daimin Wei6Center for Reproductive Medicine Shandong University Jinan ChinaCenter for Reproductive Medicine Shandong University Jinan ChinaCenter for Reproductive Medicine Shandong University Jinan ChinaCenter for Reproductive Medicine Shandong University Jinan ChinaCenter for Reproductive Medicine Shandong University Jinan ChinaDepartment of Obstetrics and Gynecology The Second Hospital of Shandong University Jinan ChinaCenter for Reproductive Medicine Shandong University Jinan ChinaAbstract Introduction Accumulating studies have suggested singletons born after frozen embryo transfer (FET) were higher than those born after fresh embryo transfer (Fre‐ET). However, fewer studies had investigated the gestational age‐specific between‐group difference in birthweight. This study aimed to investigate the gestational week‐specific difference in singleton birthweight after FET vs Fre‐ET and explore potential factors that impact the difference. Material and methods In this retrospective cohort study, a total of 25 863 singletons were included. Multivariable linear regression and logistic regression were used to evaluate the between‐group differences in mean birthweight and the incidences of large for gestational age (LGA) and small for gestational age (SGA), respectively. Results Multivariable regression analyses showed a statistically significant interaction between types of embryo transfer (ie FET vs Fre‐ET) and the gestational week on mean birthweight (P < 0.001) and on the risks of large for gestational age (P = 0.001) and small for gestational age (P < 0.001). When stratified by gestational week, the differences in mean birthweight and the risks of LGA and SGA were only observed in singletons born at 37 gestational weeks or later. After adjusting for confounders, full‐term but not preterm singletons born after FET had a higher birthweight (3497.58 ± 439.73 g vs 3445.67 ± 450.24 g; adjusted mean difference 58.35 g; 95% confidence interval [CI] 38.72–77.98 g), a higher risk of LGA (24.3% vs 21.1%; adjusted odds ratio [OR] 1.28, 95% CI 1.15–1.42) and a lower risk of SGA (3.1% vs 4.8%; adjusted OR 0.61, 95% CI 0.53–0.70) compared with those born after Fre‐ET. Conclusions The differences in birthweight between FET and Fre‐ET were observed in full‐term singletons but not preterm singletons.https://doi.org/10.1111/aogs.14503birthweightfresh embryo transferfrozen embryo transferlarge for gestational agesmall for gestational age |
| spellingShingle | Qiaoqiao Ding Yuhuan Wang Lu Suo Yue Niu Dingying Zhao Yunhai Yu Daimin Wei The gestational age‐specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort study Acta Obstetricia et Gynecologica Scandinavica birthweight fresh embryo transfer frozen embryo transfer large for gestational age small for gestational age |
| title | The gestational age‐specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort study |
| title_full | The gestational age‐specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort study |
| title_fullStr | The gestational age‐specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort study |
| title_full_unstemmed | The gestational age‐specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort study |
| title_short | The gestational age‐specific difference in birthweight between singletons born after fresh and frozen embryo transfer: A cohort study |
| title_sort | gestational age specific difference in birthweight between singletons born after fresh and frozen embryo transfer a cohort study |
| topic | birthweight fresh embryo transfer frozen embryo transfer large for gestational age small for gestational age |
| url | https://doi.org/10.1111/aogs.14503 |
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