RNA-seq analyses reveal the relevance of RNAs involved in ribosomal complex to induce mammalian prion protein aggregation and phase separation in vitro

RNA-seq analyses reveal the relevance of RNAs involved in ribosomal complex to induce mammalian prion protein aggregation and phase separation in vitro

Conformational conversion of cellular prion protein (PrPC) into infectious PrP (PrPSc) is one of the most intriguing processes in modern Biology. It is well accepted that this transition is catalysed by one or more cofactors that lower the energy barrier between the different PrP forms. Among potent...

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Main Authors: Ana C. Tahira, Mariana P. B. Gomes, Maria Heloisa Freire, Marcelly Muxfeldt, Francisco Prosdocimi, Yulli M. Passos, Murilo Sena Amaral, Leticia P. Felix Valadão, Luciana P. Rangel, Jerson L. Silva, Sergio Verjovski-Almeida, Yraima Cordeiro
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:RNA Biology
Subjects:
Prion protein
RNA-seq
ChIP-seq
prion diseases
RNA
nucleic acid
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2025.2508107
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https://www.tandfonline.com/doi/10.1080/15476286.2025.2508107

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