Nerve Sheath Myxoma Masquerading as a Parotid Tumor-A Clinical Case Report
This case report discusses a rare instance of Nerve Sheath Myxoma (NSM), a benign tumour originating from peripheral nerve Schwann cells. While typically found in the distal extremities, this case involved a 10-year-old girl with a mass in the parotid region, presenting a unique challenge in diagnos...
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| Format: | Article |
| Language: | English |
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Istanbul University Press
2025-03-01
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| Series: | The Turkish Journal of Ear Nose and Throat |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/00029E8D453B4FE7B40094FDD0C6B428 |
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| author | Vandana Malik Geetika Khanna Priyadharshini Bargunam Rohit Bhardwaj |
| author_facet | Vandana Malik Geetika Khanna Priyadharshini Bargunam Rohit Bhardwaj |
| author_sort | Vandana Malik |
| collection | DOAJ |
| description | This case report discusses a rare instance of Nerve Sheath Myxoma (NSM), a benign tumour originating from peripheral nerve Schwann cells. While typically found in the distal extremities, this case involved a 10-year-old girl with a mass in the parotid region, presenting a unique challenge in diagnosis. Initial clinical assessments suggested a benign salivary gland tumour, but inconclusive FNAC results and conflicting CE-MRI findings led to the excision of the lesion. Histopathological examination revealed a well-circumscribed, multinodular hypocellular myxoid tumour consistent with NSM. Immunohistochem istry confirmed the diagnosis, showing positivity for S100, EMA, Vimentin, and CD34. This study highlights the importance of immunohistochemistry in differentiating NSM from other entities, particularly neu rothekeoma. The treatment of choice is wide local excision with tumour-free margins, and while local recurrences are reported, malignant transformation is undocumented. In conclusion, clinical and imaging techniques may struggle to accurately identify NSM, necessitating reliance on histopathology and immunohistochemistry for diagnosis. |
| format | Article |
| id | doaj-art-bf3b831db4704f6db3a2de64fb8e3d9b |
| institution | OA Journals |
| issn | 2602-4837 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | The Turkish Journal of Ear Nose and Throat |
| spelling | doaj-art-bf3b831db4704f6db3a2de64fb8e3d9b2025-08-20T02:14:19ZengIstanbul University PressThe Turkish Journal of Ear Nose and Throat2602-48372025-03-01351596310.26650/Tr-ENT.2025.1472626123456Nerve Sheath Myxoma Masquerading as a Parotid Tumor-A Clinical Case ReportVandana Malik0https://orcid.org/0009-0000-6637-6228Geetika Khanna1https://orcid.org/0000-0002-6021-1171Priyadharshini Bargunam2https://orcid.org/0000-0001-6146-5344Rohit Bhardwajhttps://orcid.org/0000-0003-4005-4719Vardhman Mahavir Medical College and Safdarjung Hospital, New-Delhi, IndiaVardhman Mahavir Medical College and Safdarjung Hospital, New-Delhi, IndiaVardhman Mahavir Medical College and Safdarjung Hospital, New-Delhi, IndiaThis case report discusses a rare instance of Nerve Sheath Myxoma (NSM), a benign tumour originating from peripheral nerve Schwann cells. While typically found in the distal extremities, this case involved a 10-year-old girl with a mass in the parotid region, presenting a unique challenge in diagnosis. Initial clinical assessments suggested a benign salivary gland tumour, but inconclusive FNAC results and conflicting CE-MRI findings led to the excision of the lesion. Histopathological examination revealed a well-circumscribed, multinodular hypocellular myxoid tumour consistent with NSM. Immunohistochem istry confirmed the diagnosis, showing positivity for S100, EMA, Vimentin, and CD34. This study highlights the importance of immunohistochemistry in differentiating NSM from other entities, particularly neu rothekeoma. The treatment of choice is wide local excision with tumour-free margins, and while local recurrences are reported, malignant transformation is undocumented. In conclusion, clinical and imaging techniques may struggle to accurately identify NSM, necessitating reliance on histopathology and immunohistochemistry for diagnosis.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/00029E8D453B4FE7B40094FDD0C6B428nerve sheath myxomaneurothekeomaimmunohistochemistryparotid regionhistopathologys100 protein |
| spellingShingle | Vandana Malik Geetika Khanna Priyadharshini Bargunam Rohit Bhardwaj Nerve Sheath Myxoma Masquerading as a Parotid Tumor-A Clinical Case Report The Turkish Journal of Ear Nose and Throat nerve sheath myxoma neurothekeoma immunohistochemistry parotid region histopathology s100 protein |
| title | Nerve Sheath Myxoma Masquerading as a Parotid Tumor-A Clinical Case Report |
| title_full | Nerve Sheath Myxoma Masquerading as a Parotid Tumor-A Clinical Case Report |
| title_fullStr | Nerve Sheath Myxoma Masquerading as a Parotid Tumor-A Clinical Case Report |
| title_full_unstemmed | Nerve Sheath Myxoma Masquerading as a Parotid Tumor-A Clinical Case Report |
| title_short | Nerve Sheath Myxoma Masquerading as a Parotid Tumor-A Clinical Case Report |
| title_sort | nerve sheath myxoma masquerading as a parotid tumor a clinical case report |
| topic | nerve sheath myxoma neurothekeoma immunohistochemistry parotid region histopathology s100 protein |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/00029E8D453B4FE7B40094FDD0C6B428 |
| work_keys_str_mv | AT vandanamalik nervesheathmyxomamasqueradingasaparotidtumoraclinicalcasereport AT geetikakhanna nervesheathmyxomamasqueradingasaparotidtumoraclinicalcasereport AT priyadharshinibargunam nervesheathmyxomamasqueradingasaparotidtumoraclinicalcasereport AT rohitbhardwaj nervesheathmyxomamasqueradingasaparotidtumoraclinicalcasereport |