Molecular Dynamics Simulation Study of Stabilizer Association with the Val122Ile Transthyretin Variant

Molecular Dynamics Simulation Study of Stabilizer Association with the Val122Ile Transthyretin Variant

The tetrameric protein transthyretin (TTR) transports the hormone thyroxine in plasma and cerebrospinal fluid. Certain point mutations of TTR, including the Val122Ile mutation investigated here, destabilize the tetramer leading to its dissociation, misfolding, aggregation, and the eventual buildup o...

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Bibliographic Details
Main Authors: Kevin Morris, John DeSalvo, Iman Deanparvar, Lucus Schneider, Kaleigh Leach, Matthew George, Yayin Fang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biophysica
Subjects:
molecular dynamic simulation
transthyretin
kinetic stabilizer
Online Access:https://www.mdpi.com/2673-4125/5/2/16
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