Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium
The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-κB, which has key roles in inflammation and apoptosis. We hypothesized that CYLD may regulate the NF-κB signaling pathway in cholesteatoma. We conducted immunohistochemistry to examine the expression of CYLD an...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/796315 |
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| _version_ | 1850177411807707136 |
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| author | Jae Yong Byun Tae Young Yune Jee Youn Lee Seung Geun Yeo Moon Suh Park |
| author_facet | Jae Yong Byun Tae Young Yune Jee Youn Lee Seung Geun Yeo Moon Suh Park |
| author_sort | Jae Yong Byun |
| collection | DOAJ |
| description | The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-κB, which has key roles in inflammation and apoptosis. We hypothesized that CYLD may regulate the NF-κB signaling pathway in cholesteatoma. We conducted immunohistochemistry to examine the expression of CYLD and NF-κB in 16 cases of cholesteatoma and paired cases of retroauricular (RA) skin. In cholesteatoma epithelium, activated NF-κ
B expression was significantly higher than in RA skin, whereas CYLD expression was significantly lower in cholesteatoma epithelium than in RA skin (P<.05). Furthermore, a significant inverse correlation was detected between CYLD and activated NF-κB expression in cholesteatoma epithelium (r=-0.630). We found that CYLD reduced and activated increased NF-κB in cholesteatoma epithelium in comparison to RA skin. The inverse correlation between CYLD and activated NF-κB in cholesteatoma may be involved in cholesteatoma epithelial hyperplasia. |
| format | Article |
| id | doaj-art-bf394764634c48248c0cdca7fe958ade |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-bf394764634c48248c0cdca7fe958ade2025-08-20T02:18:58ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/796315796315Expression of CYLD and NF-κB in Human Cholesteatoma EpitheliumJae Yong Byun0Tae Young Yune1Jee Youn Lee2Seung Geun Yeo3Moon Suh Park4Department of Otolaryngology, School of Medicine, Kyung Hee University Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South KoreaAge-Related and Brain Diseases Research Center, Kyung Hee University, Seoul 130-701, South KoreaAge-Related and Brain Diseases Research Center, Kyung Hee University, Seoul 130-701, South KoreaDepartment of Otolaryngology, School of Medicine, Kyung Hee University Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South KoreaDepartment of Otolaryngology, School of Medicine, Kyung Hee University Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South KoreaThe tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-κB, which has key roles in inflammation and apoptosis. We hypothesized that CYLD may regulate the NF-κB signaling pathway in cholesteatoma. We conducted immunohistochemistry to examine the expression of CYLD and NF-κB in 16 cases of cholesteatoma and paired cases of retroauricular (RA) skin. In cholesteatoma epithelium, activated NF-κ B expression was significantly higher than in RA skin, whereas CYLD expression was significantly lower in cholesteatoma epithelium than in RA skin (P<.05). Furthermore, a significant inverse correlation was detected between CYLD and activated NF-κB expression in cholesteatoma epithelium (r=-0.630). We found that CYLD reduced and activated increased NF-κB in cholesteatoma epithelium in comparison to RA skin. The inverse correlation between CYLD and activated NF-κB in cholesteatoma may be involved in cholesteatoma epithelial hyperplasia.http://dx.doi.org/10.1155/2010/796315 |
| spellingShingle | Jae Yong Byun Tae Young Yune Jee Youn Lee Seung Geun Yeo Moon Suh Park Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium Mediators of Inflammation |
| title | Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium |
| title_full | Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium |
| title_fullStr | Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium |
| title_full_unstemmed | Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium |
| title_short | Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium |
| title_sort | expression of cyld and nf κb in human cholesteatoma epithelium |
| url | http://dx.doi.org/10.1155/2010/796315 |
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