Folate receptor alpha for cancer therapy: an antibody and antibody-drug conjugate target coming of age

Folate receptor alpha for cancer therapy: an antibody and antibody-drug conjugate target coming of age

Folate receptor alpha (FRα) has long been the focus of therapeutics development in oncology across several solid tumors, notably ovarian, lung, and subsets of breast cancers. Its multiple roles in cellular metabolism and carcinogenesis and tumor-specific overexpression relative to normal tissues ren...

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Bibliographic Details
Main Authors: Yi Liu, Xinyi Chen, Theodore Evan, Benjamina Esapa, Alicia Chenoweth, Anthony Cheung, Sophia N Karagiannis
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
ADC
antibody
folate receptor alpha
FRα
oncology
targeted therapy
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2470309
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