Age-related macular degeneration associated with optic disc drusen
ObjectiveThe aim of this study was to investigate the risk of age-related macular degeneration (AMD) in association with optic disc drusen (ODD).DesignThis was an observational, cross-sectional study.ParticipantsParticipants were consecutive patients with and without ODD from the neuro-ophthalmology...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Ophthalmology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fopht.2025.1620616/full |
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| author | Anas Alkhabaz Min Young Kim Min Young Kim Rishita Pujari Jamie Zhang Yulan Ren Loh-Shan Bryan Leung Yaping Joyce Liao |
| author_facet | Anas Alkhabaz Min Young Kim Min Young Kim Rishita Pujari Jamie Zhang Yulan Ren Loh-Shan Bryan Leung Yaping Joyce Liao |
| author_sort | Anas Alkhabaz |
| collection | DOAJ |
| description | ObjectiveThe aim of this study was to investigate the risk of age-related macular degeneration (AMD) in association with optic disc drusen (ODD).DesignThis was an observational, cross-sectional study.ParticipantsParticipants were consecutive patients with and without ODD from the neuro-ophthalmology clinic. Ten patients with concomitant ODD-AMD were sub-analyzed.MethodsThe two cohorts were identified from a prospectively recruited dataset between July 2022 and June 2024. Patients received formal diagnoses of ODD and AMD after ophthalmic and imaging assessment. A logistic regression model was utilized in calculating AMD risk to account for demographic differences.ResultsA total of 94 patients with ODD (median age: 44 [Q1: 20, Q3: 69], 64% women) and 100 patients without ODD (median age: 60 [Q1: 44, Q3: 69], 48% women) were identified. AMD was observed in 9.6% and 3% of the ODD and non-ODD cohorts, respectively. The risk of AMD was higher in the ODD group (OR = 3.93, 95% CI: 0.89–21.85, p = 0.084). Although the association was not statistically significant, a logistic regression model attributed that to the age difference between the two cohorts. Of the 10 patients with ODD-AMD, 70% had a family history of AMD. These patients were all Caucasians and had a median age of 75 years (range: 56–91); 70% were women. Only 30% were smokers. On optic disc imaging, 70% of eyes demonstrated moderate-to-severe ODD.ConclusionPatients with ODD might be at a higher risk of AMD compared to patients without ODD, and AMD screening might be warranted. A family history of AMD is often present, indicating shared genetic risk factors. |
| format | Article |
| id | doaj-art-bf3318c912614ba198fcd65276f6fa0b |
| institution | OA Journals |
| issn | 2674-0826 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Ophthalmology |
| spelling | doaj-art-bf3318c912614ba198fcd65276f6fa0b2025-08-20T02:38:30ZengFrontiers Media S.A.Frontiers in Ophthalmology2674-08262025-07-01510.3389/fopht.2025.16206161620616Age-related macular degeneration associated with optic disc drusenAnas Alkhabaz0Min Young Kim1Min Young Kim2Rishita Pujari3Jamie Zhang4Yulan Ren5Loh-Shan Bryan Leung6Yaping Joyce Liao7Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, CA, United StatesOakland University William Beaumont School of Medicine, Rochester, MI, United StatesDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, CA, United StatesObjectiveThe aim of this study was to investigate the risk of age-related macular degeneration (AMD) in association with optic disc drusen (ODD).DesignThis was an observational, cross-sectional study.ParticipantsParticipants were consecutive patients with and without ODD from the neuro-ophthalmology clinic. Ten patients with concomitant ODD-AMD were sub-analyzed.MethodsThe two cohorts were identified from a prospectively recruited dataset between July 2022 and June 2024. Patients received formal diagnoses of ODD and AMD after ophthalmic and imaging assessment. A logistic regression model was utilized in calculating AMD risk to account for demographic differences.ResultsA total of 94 patients with ODD (median age: 44 [Q1: 20, Q3: 69], 64% women) and 100 patients without ODD (median age: 60 [Q1: 44, Q3: 69], 48% women) were identified. AMD was observed in 9.6% and 3% of the ODD and non-ODD cohorts, respectively. The risk of AMD was higher in the ODD group (OR = 3.93, 95% CI: 0.89–21.85, p = 0.084). Although the association was not statistically significant, a logistic regression model attributed that to the age difference between the two cohorts. Of the 10 patients with ODD-AMD, 70% had a family history of AMD. These patients were all Caucasians and had a median age of 75 years (range: 56–91); 70% were women. Only 30% were smokers. On optic disc imaging, 70% of eyes demonstrated moderate-to-severe ODD.ConclusionPatients with ODD might be at a higher risk of AMD compared to patients without ODD, and AMD screening might be warranted. A family history of AMD is often present, indicating shared genetic risk factors.https://www.frontiersin.org/articles/10.3389/fopht.2025.1620616/fulloptic disc drusenage-related macular degenerationmultimodal imagingmacular drusencalcification |
| spellingShingle | Anas Alkhabaz Min Young Kim Min Young Kim Rishita Pujari Jamie Zhang Yulan Ren Loh-Shan Bryan Leung Yaping Joyce Liao Age-related macular degeneration associated with optic disc drusen Frontiers in Ophthalmology optic disc drusen age-related macular degeneration multimodal imaging macular drusen calcification |
| title | Age-related macular degeneration associated with optic disc drusen |
| title_full | Age-related macular degeneration associated with optic disc drusen |
| title_fullStr | Age-related macular degeneration associated with optic disc drusen |
| title_full_unstemmed | Age-related macular degeneration associated with optic disc drusen |
| title_short | Age-related macular degeneration associated with optic disc drusen |
| title_sort | age related macular degeneration associated with optic disc drusen |
| topic | optic disc drusen age-related macular degeneration multimodal imaging macular drusen calcification |
| url | https://www.frontiersin.org/articles/10.3389/fopht.2025.1620616/full |
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