Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer
This article presents methods and results of surgery and radiotherapy of brain metastases from non-small cell lung cancer (BMF-NSCLC). Patients with single BMF-NSCLC, with Karnofsky score ≥ 70 and controlled extracranial disease are the best candidates for surgery. Stereotactic radiosurgery (SRS) is...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2016-12-01
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| Series: | Contemporary Oncology |
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| Online Access: | https://www.termedia.pl/Methods-and-results-of-locoregional-treatment-of-brain-metastases-in-patients-with-non-small-cell-lung-cancer,3,25183,1,1.html |
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| author | Anna Patla Tomasz Walasek Jerzy Jakubowicz Paweł Blecharz Jerzy Władysław Mituś Anna Mucha-Małecka Marian Reinfuss |
| author_facet | Anna Patla Tomasz Walasek Jerzy Jakubowicz Paweł Blecharz Jerzy Władysław Mituś Anna Mucha-Małecka Marian Reinfuss |
| author_sort | Anna Patla |
| collection | DOAJ |
| description | This article presents methods and results of surgery and radiotherapy of brain metastases from non-small cell lung cancer (BMF-NSCLC). Patients with single BMF-NSCLC, with Karnofsky score ≥ 70 and controlled extracranial disease are the best candidates for surgery. Stereotactic radiosurgery (SRS) is recommended in patients with 1–3 BMF-NSCLC below 3–3.5 cm, with minor neurological symptoms, located in parts of the brain not accessible to surgery, with controlled extracranial disease. Whole brain radiotherapy (WBRT) following SRS reduces the risk of local relapse; in selected patients median survival reaches more than 10 months. Whole brain radiotherapy alone is
a treatment in patients with multiple metastases, poor performance status, uncontrolled extracranial disease, disqualified from surgery or SRS with median survival 3 to 6 months. There is no doubt that there are patients with BMF-NSCLC who should receive only the best supportive care. There is a debate in the literature on how to select these patients. |
| format | Article |
| id | doaj-art-bf30e16e8f56456982eb660c4f69d9af |
| institution | OA Journals |
| issn | 1428-2526 1897-4309 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Contemporary Oncology |
| spelling | doaj-art-bf30e16e8f56456982eb660c4f69d9af2025-08-20T02:18:42ZengTermedia Publishing HouseContemporary Oncology1428-25261897-43092016-12-0120535836410.5114/wo.2015.5182525183Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancerAnna PatlaTomasz WalasekJerzy JakubowiczPaweł BlecharzJerzy Władysław MituśAnna Mucha-MałeckaMarian ReinfussThis article presents methods and results of surgery and radiotherapy of brain metastases from non-small cell lung cancer (BMF-NSCLC). Patients with single BMF-NSCLC, with Karnofsky score ≥ 70 and controlled extracranial disease are the best candidates for surgery. Stereotactic radiosurgery (SRS) is recommended in patients with 1–3 BMF-NSCLC below 3–3.5 cm, with minor neurological symptoms, located in parts of the brain not accessible to surgery, with controlled extracranial disease. Whole brain radiotherapy (WBRT) following SRS reduces the risk of local relapse; in selected patients median survival reaches more than 10 months. Whole brain radiotherapy alone is a treatment in patients with multiple metastases, poor performance status, uncontrolled extracranial disease, disqualified from surgery or SRS with median survival 3 to 6 months. There is no doubt that there are patients with BMF-NSCLC who should receive only the best supportive care. There is a debate in the literature on how to select these patients.https://www.termedia.pl/Methods-and-results-of-locoregional-treatment-of-brain-metastases-in-patients-with-non-small-cell-lung-cancer,3,25183,1,1.htmlnon-small cell lung cancer brain metastases radiation therapy |
| spellingShingle | Anna Patla Tomasz Walasek Jerzy Jakubowicz Paweł Blecharz Jerzy Władysław Mituś Anna Mucha-Małecka Marian Reinfuss Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer Contemporary Oncology non-small cell lung cancer brain metastases radiation therapy |
| title | Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer |
| title_full | Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer |
| title_fullStr | Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer |
| title_full_unstemmed | Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer |
| title_short | Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer |
| title_sort | methods and results of locoregional treatment of brain metastases in patients with non small cell lung cancer |
| topic | non-small cell lung cancer brain metastases radiation therapy |
| url | https://www.termedia.pl/Methods-and-results-of-locoregional-treatment-of-brain-metastases-in-patients-with-non-small-cell-lung-cancer,3,25183,1,1.html |
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