Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure
Aim. To assess the effect of renal dysfunction on the galectin-3 level in patients with chronic heart failure (HF) with preserved, intermediate and reduced left ventricular ejection fraction (EF).Material and methods. Along with a clinical examination, 69 patients with HF (NYHA class II-IV) underwen...
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Столичная издательская компания
2022-05-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2709 |
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| author | V. I. Podzolkov N. A. Dragomiretskaya A. V. Kazadaeva Yu. G. Belyaev A. V. Tolmacheva |
| author_facet | V. I. Podzolkov N. A. Dragomiretskaya A. V. Kazadaeva Yu. G. Belyaev A. V. Tolmacheva |
| author_sort | V. I. Podzolkov |
| collection | DOAJ |
| description | Aim. To assess the effect of renal dysfunction on the galectin-3 level in patients with chronic heart failure (HF) with preserved, intermediate and reduced left ventricular ejection fraction (EF).Material and methods. Along with a clinical examination, 69 patients with HF (NYHA class II-IV) underwent tests for the level of NT-proBNP and galectin-3 in serum using enzyme immunoassay.Results. Study participants were divided into 3 groups: 23 patients with preserved EF (HFpEF), 26 patients with midrange EF (HFmrEF), 20 patients with reduced EF (HFrEF). There was a trend to increase the concentration of galectin-3 with increase in NT-proBNP level. Correlation analysis showed significant feedback (r=−0.41, p<0.05) between galectin-3 and EF only in patients with preserved systolic function. In the same group of HFpEF patients, the maximum serum galectin-3 level was 10.5 [6.5; 14.5] ng/ml. Serum galectin-3 level showed negative correlated with the GFR in patients with CHF (r=−0.513, p<0.05). In patients with HF and glomerular filtration rate (GFR) <60 ml/min/1.73 m2 it was higher than in patients with GFR>60 ml/min/1.72 m2 (9 [5.3; 12.6] ng/mL vs 11.8 [6.2; 15.3] ng/mL, p<0.05). According to the ROC-analysis data, galectin-3 level >10.3 ng/ml indicates a high risk of chronic kidney disease stage 3-4 stage development (sensitivity 60%, specificity 75%) and can be considered as a risk factor for development of cardiorenal syndrome in HF patients.Conclusion. Galectin-3 level in patients with HF is more influenced by the degree of reduction in GFR rather than the left ventricular systolic function impairment. |
| format | Article |
| id | doaj-art-bf2c502db8a24cbf87da66f1a036d470 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-bf2c502db8a24cbf87da66f1a036d4702025-08-23T10:00:35ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532022-05-0118215315910.20996/1819-6446-2022-04-042004Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart FailureV. I. Podzolkov0N. A. Dragomiretskaya1A. V. Kazadaeva2Yu. G. Belyaev3A. V. Tolmacheva4I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim. To assess the effect of renal dysfunction on the galectin-3 level in patients with chronic heart failure (HF) with preserved, intermediate and reduced left ventricular ejection fraction (EF).Material and methods. Along with a clinical examination, 69 patients with HF (NYHA class II-IV) underwent tests for the level of NT-proBNP and galectin-3 in serum using enzyme immunoassay.Results. Study participants were divided into 3 groups: 23 patients with preserved EF (HFpEF), 26 patients with midrange EF (HFmrEF), 20 patients with reduced EF (HFrEF). There was a trend to increase the concentration of galectin-3 with increase in NT-proBNP level. Correlation analysis showed significant feedback (r=−0.41, p<0.05) between galectin-3 and EF only in patients with preserved systolic function. In the same group of HFpEF patients, the maximum serum galectin-3 level was 10.5 [6.5; 14.5] ng/ml. Serum galectin-3 level showed negative correlated with the GFR in patients with CHF (r=−0.513, p<0.05). In patients with HF and glomerular filtration rate (GFR) <60 ml/min/1.73 m2 it was higher than in patients with GFR>60 ml/min/1.72 m2 (9 [5.3; 12.6] ng/mL vs 11.8 [6.2; 15.3] ng/mL, p<0.05). According to the ROC-analysis data, galectin-3 level >10.3 ng/ml indicates a high risk of chronic kidney disease stage 3-4 stage development (sensitivity 60%, specificity 75%) and can be considered as a risk factor for development of cardiorenal syndrome in HF patients.Conclusion. Galectin-3 level in patients with HF is more influenced by the degree of reduction in GFR rather than the left ventricular systolic function impairment.https://www.rpcardio.online/jour/article/view/2709galectin-3chronic heart failurecardiorenal syndrome |
| spellingShingle | V. I. Podzolkov N. A. Dragomiretskaya A. V. Kazadaeva Yu. G. Belyaev A. V. Tolmacheva Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure Рациональная фармакотерапия в кардиологии galectin-3 chronic heart failure cardiorenal syndrome |
| title | Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure |
| title_full | Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure |
| title_fullStr | Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure |
| title_full_unstemmed | Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure |
| title_short | Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure |
| title_sort | galectin 3 as a marker of cardiorenal syndrome in patients with chronic heart failure |
| topic | galectin-3 chronic heart failure cardiorenal syndrome |
| url | https://www.rpcardio.online/jour/article/view/2709 |
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