Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances
Plant-derived compounds have attracted considerable attention in the field of antimicrobial therapy. This interest is primarily due to their natural origin and historical evidence of their use in traditional medicine systems. These derivatives are a rich reservoir of chemical diversity that has a pr...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/ijbm/4251091 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849249318865731584 |
|---|---|
| author | Mohammad Hashem Hashempur Fereshteh Ghorat Forough Karami Alireza Jahanbin Hasti Nouraei Milad Abbasi Mahboobeh Jafari Alireza Zare Sajjad Barzegar Zahra Zareshahrabadi |
| author_facet | Mohammad Hashem Hashempur Fereshteh Ghorat Forough Karami Alireza Jahanbin Hasti Nouraei Milad Abbasi Mahboobeh Jafari Alireza Zare Sajjad Barzegar Zahra Zareshahrabadi |
| author_sort | Mohammad Hashem Hashempur |
| collection | DOAJ |
| description | Plant-derived compounds have attracted considerable attention in the field of antimicrobial therapy. This interest is primarily due to their natural origin and historical evidence of their use in traditional medicine systems. These derivatives are a rich reservoir of chemical diversity that has a promising potential for the development and production of new antimicrobial agents with the least amount of side effects and risks of drug resistance. However, the delivery of plant-derived antimicrobial agents, especially through the topical route, poses significant challenges. As the largest organ of the body, the skin acts as a first barrier against the entrance of microbial pathogens. A primary limitation to transdermal delivery of plant-derived antimicrobial agents is their complex molecular structures, which often prevent effective absorption through the skin. Therefore, developing and promoting an effective local drug delivery system to increase the potential of antimicrobial therapy is very important and effective in public health. This review discusses delivery strategies for plant-derived antimicrobial agents aimed at the bioavailability and stability of these compounds as well as their mode of action, ensuring targeted delivery to the site of infection with long-lasting effects and minimizing side effects. Besides, various topical drug delivery platforms are analyzed, including nanoparticles, liposomes, and innovative application methods such as microneedles. |
| format | Article |
| id | doaj-art-bf2863df42fb47ab80e046c075fff645 |
| institution | Kabale University |
| issn | 1687-8795 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-bf2863df42fb47ab80e046c075fff6452025-08-20T03:57:36ZengWileyInternational Journal of Biomaterials1687-87952025-01-01202510.1155/ijbm/4251091Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current AdvancesMohammad Hashem Hashempur0Fereshteh Ghorat1Forough Karami2Alireza Jahanbin3Hasti Nouraei4Milad Abbasi5Mahboobeh Jafari6Alireza Zare7Sajjad Barzegar8Zahra Zareshahrabadi9Research Center for Traditional Medicine and History of MedicineNon-Communicable Diseases Research CenterCentral Research LaboratoryDepartment of Materials Science and EngineeringDepartment of Parasitology and MycologyDepartment of Medical NanotechnologyCenter for Nanotechnology in Drug DeliveryDepartment of Medical NanotechnologyDepartment of Chemical EngineeringBasic Sciences in Infectious Diseases Research CenterPlant-derived compounds have attracted considerable attention in the field of antimicrobial therapy. This interest is primarily due to their natural origin and historical evidence of their use in traditional medicine systems. These derivatives are a rich reservoir of chemical diversity that has a promising potential for the development and production of new antimicrobial agents with the least amount of side effects and risks of drug resistance. However, the delivery of plant-derived antimicrobial agents, especially through the topical route, poses significant challenges. As the largest organ of the body, the skin acts as a first barrier against the entrance of microbial pathogens. A primary limitation to transdermal delivery of plant-derived antimicrobial agents is their complex molecular structures, which often prevent effective absorption through the skin. Therefore, developing and promoting an effective local drug delivery system to increase the potential of antimicrobial therapy is very important and effective in public health. This review discusses delivery strategies for plant-derived antimicrobial agents aimed at the bioavailability and stability of these compounds as well as their mode of action, ensuring targeted delivery to the site of infection with long-lasting effects and minimizing side effects. Besides, various topical drug delivery platforms are analyzed, including nanoparticles, liposomes, and innovative application methods such as microneedles.http://dx.doi.org/10.1155/ijbm/4251091 |
| spellingShingle | Mohammad Hashem Hashempur Fereshteh Ghorat Forough Karami Alireza Jahanbin Hasti Nouraei Milad Abbasi Mahboobeh Jafari Alireza Zare Sajjad Barzegar Zahra Zareshahrabadi Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances International Journal of Biomaterials |
| title | Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances |
| title_full | Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances |
| title_fullStr | Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances |
| title_full_unstemmed | Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances |
| title_short | Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances |
| title_sort | topical delivery systems for plant derived antimicrobial agents a review of current advances |
| url | http://dx.doi.org/10.1155/ijbm/4251091 |
| work_keys_str_mv | AT mohammadhashemhashempur topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT fereshtehghorat topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT foroughkarami topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT alirezajahanbin topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT hastinouraei topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT miladabbasi topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT mahboobehjafari topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT alirezazare topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT sajjadbarzegar topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances AT zahrazareshahrabadi topicaldeliverysystemsforplantderivedantimicrobialagentsareviewofcurrentadvances |