The Effects of HLA-G Gene Polymorphism and sHLA-G Level in Women with Threatened Abortion
The most frequent first-trimester problem is a miscarriage, which affects 20% of pregnancies. In approximately 20-25 percent of confirmed pregnancies, threatened miscarriage is indeed a risk factor that may develop or resolve. This study aimed to assess the impact of certain HLA-G gene SNPs and sHL...
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middle technical university
2022-06-01
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| Series: | Journal of Techniques |
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| Online Access: | https://journal.mtu.edu.iq/index.php/MTU/article/view/505 |
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| author | Ahmed H. Merdas Mayada N. Iqbal Nisreen Sherif Alyasiri |
| author_facet | Ahmed H. Merdas Mayada N. Iqbal Nisreen Sherif Alyasiri |
| author_sort | Ahmed H. Merdas |
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The most frequent first-trimester problem is a miscarriage, which affects 20% of pregnancies. In approximately 20-25 percent of confirmed pregnancies, threatened miscarriage is indeed a risk factor that may develop or resolve. This study aimed to assess the impact of certain HLA-G gene SNPs and sHLA-G serum levels to determine whether they play a role in threatening abortions. This study included 90 subjects who were separated into three groups: 30 patients (threatened abortion patients), and 60 controls (30 healthy pregnant women and 30 healthy non-pregnant women). All of the study groups were between the ages of 20 and 35 years old. The mean sHLA-G level in pregnant women's sera was found to be 430.38 Pg/ml, compared to 307.98 Pg/ml in the threatened abortion group and 192.11 Pg/ml in non-pregnant women (P= 0.001). The rs2249863 T/C/G was a statistically significant difference between the T allele and the G allele, with an odds ratio of 1.720 (p-value = 0.038). In conclusion, serum sHLA-G levels in threatened abortion patients' sera are significantly lower than in normal pregnant women. Allele frequencies of HLA-G gene snps were non-significant changes between TA patients and controls, except rs2249863 T/C/G.
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| format | Article |
| id | doaj-art-bf1d13d00f0742a5b0c1098966c4494a |
| institution | Kabale University |
| issn | 1818-653X 2708-8383 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | middle technical university |
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| series | Journal of Techniques |
| spelling | doaj-art-bf1d13d00f0742a5b0c1098966c4494a2025-01-19T11:07:14Zengmiddle technical universityJournal of Techniques1818-653X2708-83832022-06-014210.51173/jt.v4i2.505The Effects of HLA-G Gene Polymorphism and sHLA-G Level in Women with Threatened AbortionAhmed H. Merdas0Mayada N. Iqbal1Nisreen Sherif Alyasiri2College of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, IraqCollege of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, IraqTechnical Institute \ Alsuwayra, Middle Technical University, Baghdad, Iraq The most frequent first-trimester problem is a miscarriage, which affects 20% of pregnancies. In approximately 20-25 percent of confirmed pregnancies, threatened miscarriage is indeed a risk factor that may develop or resolve. This study aimed to assess the impact of certain HLA-G gene SNPs and sHLA-G serum levels to determine whether they play a role in threatening abortions. This study included 90 subjects who were separated into three groups: 30 patients (threatened abortion patients), and 60 controls (30 healthy pregnant women and 30 healthy non-pregnant women). All of the study groups were between the ages of 20 and 35 years old. The mean sHLA-G level in pregnant women's sera was found to be 430.38 Pg/ml, compared to 307.98 Pg/ml in the threatened abortion group and 192.11 Pg/ml in non-pregnant women (P= 0.001). The rs2249863 T/C/G was a statistically significant difference between the T allele and the G allele, with an odds ratio of 1.720 (p-value = 0.038). In conclusion, serum sHLA-G levels in threatened abortion patients' sera are significantly lower than in normal pregnant women. Allele frequencies of HLA-G gene snps were non-significant changes between TA patients and controls, except rs2249863 T/C/G. https://journal.mtu.edu.iq/index.php/MTU/article/view/505sHLA-GHLA-G genesnpsThreatened AbortionPregnancy |
| spellingShingle | Ahmed H. Merdas Mayada N. Iqbal Nisreen Sherif Alyasiri The Effects of HLA-G Gene Polymorphism and sHLA-G Level in Women with Threatened Abortion Journal of Techniques sHLA-G HLA-G gene snps Threatened Abortion Pregnancy |
| title | The Effects of HLA-G Gene Polymorphism and sHLA-G Level in Women with Threatened Abortion |
| title_full | The Effects of HLA-G Gene Polymorphism and sHLA-G Level in Women with Threatened Abortion |
| title_fullStr | The Effects of HLA-G Gene Polymorphism and sHLA-G Level in Women with Threatened Abortion |
| title_full_unstemmed | The Effects of HLA-G Gene Polymorphism and sHLA-G Level in Women with Threatened Abortion |
| title_short | The Effects of HLA-G Gene Polymorphism and sHLA-G Level in Women with Threatened Abortion |
| title_sort | effects of hla g gene polymorphism and shla g level in women with threatened abortion |
| topic | sHLA-G HLA-G gene snps Threatened Abortion Pregnancy |
| url | https://journal.mtu.edu.iq/index.php/MTU/article/view/505 |
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