Improved safety of chimeric antigen receptor T cells indirectly targeting antigens via switchable adapters

Improved safety of chimeric antigen receptor T cells indirectly targeting antigens via switchable adapters

Abstract Chimeric antigen receptor T (CAR-T) cells show remarkable efficacy for some hematological malignancies. However, CAR targets that are expressed at high level and selective to tumors are scarce. Several strategies have been proposed to tackle the on-target off-tumor toxicity of CAR-T cells t...

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Main Authors: Hyung Bae Park, Ki Hyun Kim, Ju Hwan Kim, Sang Il Kim, Yu Mi Oh, Miseung Kang, Seoho Lee, Siwon Hwang, Hyeonmin Lee, TaeJin Lee, Seungbin Park, Ji Eun Lee, Ga Ram Jeong, Dong Hyun Lee, Hyewon Youn, Eun Young Choi, Woo Chan Son, Sang J. Chung, Junho Chung, Kyungho Choi
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53996-7
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