DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis
Abstract The DNA cross-link repair 1B (DCLRE1B) gene is involved in repairing cross-links between DNA strands, including those associated with Hoyeraal–Hreidarsson syndrome and congenital dyskeratosis. However, its role in tumours is not well understood. DCLRE1B expression profiles were examined in...
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-80603-y |
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| author | Mi Zou Zuxi Feng Kaibo Hu Yuan Shu Ting Li Xiaogang Peng Leifeng Chen Leyang Xiao Shouhua Zhang Ting Xiong Xueqiang Deng Jie Peng Liang Hao |
| author_facet | Mi Zou Zuxi Feng Kaibo Hu Yuan Shu Ting Li Xiaogang Peng Leifeng Chen Leyang Xiao Shouhua Zhang Ting Xiong Xueqiang Deng Jie Peng Liang Hao |
| author_sort | Mi Zou |
| collection | DOAJ |
| description | Abstract The DNA cross-link repair 1B (DCLRE1B) gene is involved in repairing cross-links between DNA strands, including those associated with Hoyeraal–Hreidarsson syndrome and congenital dyskeratosis. However, its role in tumours is not well understood. DCLRE1B expression profiles were examined in tumour tissues and normal tissues using TCGA, GTEx, and TARGET datasets. Additionally, we performed experiments with clinical melanoma samples to verify DCLRE1B expression patterns. We also performed pancancer analyses to investigate the diverse roles of DCLRE1B in the biological functions of various cancers. DCLRE1B exhibited distinct expression patterns and played crucial prognostic roles in most tumours. In particular, high expression of DCLRE1B in melanoma was significantly correlated with a poor prognosis and increased malignancy. DCLRE1B was also found to be associated with the immune landscape and various immune biomarkers and regulators. Furthermore, our analysis identified potential small molecules that could target DCLRE1B in different cancer types. The DCLRE1B gene may be involved in the development and occurrence of a variety of cancers. Additionally, DCLRE1B affects various tumour types not only by mediating DNA repair but also by shaping the differential immune microenvironment. In conclusion, our research offers fresh perspectives on the diagnosis and treatment of different types of cancers. |
| format | Article |
| id | doaj-art-bf120885b659497aa9cce7e2f1da71a5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-bf120885b659497aa9cce7e2f1da71a52025-01-05T12:25:32ZengNature PortfolioScientific Reports2045-23222024-12-0114111610.1038/s41598-024-80603-yDCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysisMi Zou0Zuxi Feng1Kaibo Hu2Yuan Shu3Ting Li4Xiaogang Peng5Leifeng Chen6Leyang Xiao7Shouhua Zhang8Ting Xiong9Xueqiang Deng10Jie Peng11Liang Hao12Department of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityJiangxi Province Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityDepartment of General Surgery, Jiangxi Children’s HospitalDepartment of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Rehabilitation, Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang UniversityAbstract The DNA cross-link repair 1B (DCLRE1B) gene is involved in repairing cross-links between DNA strands, including those associated with Hoyeraal–Hreidarsson syndrome and congenital dyskeratosis. However, its role in tumours is not well understood. DCLRE1B expression profiles were examined in tumour tissues and normal tissues using TCGA, GTEx, and TARGET datasets. Additionally, we performed experiments with clinical melanoma samples to verify DCLRE1B expression patterns. We also performed pancancer analyses to investigate the diverse roles of DCLRE1B in the biological functions of various cancers. DCLRE1B exhibited distinct expression patterns and played crucial prognostic roles in most tumours. In particular, high expression of DCLRE1B in melanoma was significantly correlated with a poor prognosis and increased malignancy. DCLRE1B was also found to be associated with the immune landscape and various immune biomarkers and regulators. Furthermore, our analysis identified potential small molecules that could target DCLRE1B in different cancer types. The DCLRE1B gene may be involved in the development and occurrence of a variety of cancers. Additionally, DCLRE1B affects various tumour types not only by mediating DNA repair but also by shaping the differential immune microenvironment. In conclusion, our research offers fresh perspectives on the diagnosis and treatment of different types of cancers.https://doi.org/10.1038/s41598-024-80603-yDCLRE1BPancancerPrognostic biomarkerImmunotherapy responsePrognosis |
| spellingShingle | Mi Zou Zuxi Feng Kaibo Hu Yuan Shu Ting Li Xiaogang Peng Leifeng Chen Leyang Xiao Shouhua Zhang Ting Xiong Xueqiang Deng Jie Peng Liang Hao DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis Scientific Reports DCLRE1B Pancancer Prognostic biomarker Immunotherapy response Prognosis |
| title | DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis |
| title_full | DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis |
| title_fullStr | DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis |
| title_full_unstemmed | DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis |
| title_short | DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis |
| title_sort | dclre1b as a novel prognostic biomarker associated with immune infiltration a pancancer analysis |
| topic | DCLRE1B Pancancer Prognostic biomarker Immunotherapy response Prognosis |
| url | https://doi.org/10.1038/s41598-024-80603-y |
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