Mithramycin targets head and neck cancer stem cells by inhibiting Sp1 and UFMylation

Mithramycin targets head and neck cancer stem cells by inhibiting Sp1 and UFMylation

Abstract Background The development of resistance to therapy is characteristic of head and neck squamous cell carcinoma (HNSCC), the 6th most common cancer, and is often attributed to cancer stem cells (CSCs). By proteomic approach, we determined that UFMylation plays an important role in HNSCC CSCs...

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Bibliographic Details
Main Authors: Kristina Vukovic Derfi, Tea Vasiljevic, Tea Dragicevic, Tanja Matijevic Glavan
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer Cell International
Subjects:
Cancer stem cells
Head and neck cancer
Proteomics
UFMylation
Mithramycin
Online Access:https://doi.org/10.1186/s12935-024-03609-6
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