Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6
Apart from biochemical signals, tumour cells respond to biophysical and mechanical cues from their environment. The mechanical forces from the tumour microenvironment could be in the form of shear stress, tension, or solid stress compression. In this study, we explore the effects of solid stress com...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1541953/full |
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| author | Farouq Azizan Ryna Shireen Sheriff Corinna Jie Hui Goh Keng Hwee Chiam Cheng-Gee Koh |
| author_facet | Farouq Azizan Ryna Shireen Sheriff Corinna Jie Hui Goh Keng Hwee Chiam Cheng-Gee Koh |
| author_sort | Farouq Azizan |
| collection | DOAJ |
| description | Apart from biochemical signals, tumour cells respond to biophysical and mechanical cues from their environment. The mechanical forces from the tumour microenvironment could be in the form of shear stress, tension, or solid stress compression. In this study, we explore the effects of solid stress compression on tumour cells. Solid stress compression, a prevalent biomechanical stimulus accumulated during tumour growth, has been shown to enhance invasive and metastatic phenotypes in cancer cells. However, the underlying molecular mechanism that elicits this aggressive metastatic phenotype, especially in breast cancer, is not extensively studied. Using an established 2D in vitro setup to apply incremental solid stress compression, we found that migratory and invasive capacities of aggressive breast cancer cells were enhanced in a biphasic manner. We also found that the transcript and protein levels of Interleukin-6 (IL-6) and SNAI1 were upregulated in response to solid stress. The resultant increased secretion of IL-6 could in turn lead to autocrine activation of downstream signalling pathways and impact on cancer cell migration and invasion. |
| format | Article |
| id | doaj-art-bf0abd7f93e24c8c8a78533095daeeb2 |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-bf0abd7f93e24c8c8a78533095daeeb22025-08-20T02:55:42ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-04-011310.3389/fcell.2025.15419531541953Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6Farouq Azizan0Ryna Shireen Sheriff1Corinna Jie Hui Goh2Keng Hwee Chiam3Cheng-Gee Koh4School of Biological Sciences, Nanyang Technological University, Singapore, SingaporeSchool of Biological Sciences, Nanyang Technological University, Singapore, SingaporeBioinformatics Institute, Agency for Science, Technology and Research (A*Star), Biopolis, Singapore, SingaporeBioinformatics Institute, Agency for Science, Technology and Research (A*Star), Biopolis, Singapore, SingaporeSchool of Biological Sciences, Nanyang Technological University, Singapore, SingaporeApart from biochemical signals, tumour cells respond to biophysical and mechanical cues from their environment. The mechanical forces from the tumour microenvironment could be in the form of shear stress, tension, or solid stress compression. In this study, we explore the effects of solid stress compression on tumour cells. Solid stress compression, a prevalent biomechanical stimulus accumulated during tumour growth, has been shown to enhance invasive and metastatic phenotypes in cancer cells. However, the underlying molecular mechanism that elicits this aggressive metastatic phenotype, especially in breast cancer, is not extensively studied. Using an established 2D in vitro setup to apply incremental solid stress compression, we found that migratory and invasive capacities of aggressive breast cancer cells were enhanced in a biphasic manner. We also found that the transcript and protein levels of Interleukin-6 (IL-6) and SNAI1 were upregulated in response to solid stress. The resultant increased secretion of IL-6 could in turn lead to autocrine activation of downstream signalling pathways and impact on cancer cell migration and invasion.https://www.frontiersin.org/articles/10.3389/fcell.2025.1541953/fullsolid stress compressioncell migrationInterleukin-6mechanosensitive genestranscriptome |
| spellingShingle | Farouq Azizan Ryna Shireen Sheriff Corinna Jie Hui Goh Keng Hwee Chiam Cheng-Gee Koh Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6 Frontiers in Cell and Developmental Biology solid stress compression cell migration Interleukin-6 mechanosensitive genes transcriptome |
| title | Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6 |
| title_full | Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6 |
| title_fullStr | Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6 |
| title_full_unstemmed | Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6 |
| title_short | Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6 |
| title_sort | solid stress compression enhances breast cancer cell migration through the upregulation of interleukin 6 |
| topic | solid stress compression cell migration Interleukin-6 mechanosensitive genes transcriptome |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1541953/full |
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