Defining criteria for broadly neutralizing HIV antibodies
Over the course of a few years, a small percentage of individuals with HIV-1 develop broadly neutralizing antibodies (bnAbs) capable of neutralizing diverse viruses. Although hundreds of antibodies with neutralizing activity against heterologous viruses have been referred to as bnAbs, there is no un...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1624020/full |
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| author | Elizabeth-Sharon David-Fung Katherine A. Belobrajdic Jennifer P. Macke Corey R. Quackenbush Kumkum Ganguly Jennifer L. Mamrosh |
| author_facet | Elizabeth-Sharon David-Fung Katherine A. Belobrajdic Jennifer P. Macke Corey R. Quackenbush Kumkum Ganguly Jennifer L. Mamrosh |
| author_sort | Elizabeth-Sharon David-Fung |
| collection | DOAJ |
| description | Over the course of a few years, a small percentage of individuals with HIV-1 develop broadly neutralizing antibodies (bnAbs) capable of neutralizing diverse viruses. Although hundreds of antibodies with neutralizing activity against heterologous viruses have been referred to as bnAbs, there is no universally accepted numerical definition of a bnAb. Here, we will review important elements of HIV neutralizing antibodies and proposed definitions of bnAbs, as well as introduce a web-based tool, CAByN (Choose Antibodies by Neutralization), allowing users to identify antibodies meeting their numerical definitions of a bnAb from data in the Los Alamos HIV Databases CATNAP (Compile, Analyze and Tally NAb Panels) antibody neutralization database. Biological findings from use of CAByN are also presented here, including differential neutralizing activity for certain antibodies across viral clades, and identification of antibodies with suspected incomplete neutralization. Website address: http://hiv.lanl.gov/content/sequence/CABYN/CABYN.html. |
| format | Article |
| id | doaj-art-bf095a04846c4d2ebdb089938e742be3 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-bf095a04846c4d2ebdb089938e742be32025-08-20T02:40:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.16240201624020Defining criteria for broadly neutralizing HIV antibodiesElizabeth-Sharon David-FungKatherine A. BelobrajdicJennifer P. MackeCorey R. QuackenbushKumkum GangulyJennifer L. MamroshOver the course of a few years, a small percentage of individuals with HIV-1 develop broadly neutralizing antibodies (bnAbs) capable of neutralizing diverse viruses. Although hundreds of antibodies with neutralizing activity against heterologous viruses have been referred to as bnAbs, there is no universally accepted numerical definition of a bnAb. Here, we will review important elements of HIV neutralizing antibodies and proposed definitions of bnAbs, as well as introduce a web-based tool, CAByN (Choose Antibodies by Neutralization), allowing users to identify antibodies meeting their numerical definitions of a bnAb from data in the Los Alamos HIV Databases CATNAP (Compile, Analyze and Tally NAb Panels) antibody neutralization database. Biological findings from use of CAByN are also presented here, including differential neutralizing activity for certain antibodies across viral clades, and identification of antibodies with suspected incomplete neutralization. Website address: http://hiv.lanl.gov/content/sequence/CABYN/CABYN.html.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1624020/fullHIVbroadly neutralizing antibodiesBNABantibody breadthpotency |
| spellingShingle | Elizabeth-Sharon David-Fung Katherine A. Belobrajdic Jennifer P. Macke Corey R. Quackenbush Kumkum Ganguly Jennifer L. Mamrosh Defining criteria for broadly neutralizing HIV antibodies Frontiers in Immunology HIV broadly neutralizing antibodies BNAB antibody breadth potency |
| title | Defining criteria for broadly neutralizing HIV antibodies |
| title_full | Defining criteria for broadly neutralizing HIV antibodies |
| title_fullStr | Defining criteria for broadly neutralizing HIV antibodies |
| title_full_unstemmed | Defining criteria for broadly neutralizing HIV antibodies |
| title_short | Defining criteria for broadly neutralizing HIV antibodies |
| title_sort | defining criteria for broadly neutralizing hiv antibodies |
| topic | HIV broadly neutralizing antibodies BNAB antibody breadth potency |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1624020/full |
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