Computed tomography-based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement: a novel method for risk assessment
Abstract Background The coronary lumen volume to myocardial mass (V/M) ratio has been suggested as a quantitative metric of potential imbalance between coronary blood supply and myocardial oxygen demand. This study was designed to assess the prognostic value of the V/M ratio for predicting major adv...
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BMC
2025-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04705-9 |
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| author | Wenting Li Ruichen Ren Qingyuan Zhao Chengcheng Qi Zhiyu Chen Yang Zhang |
| author_facet | Wenting Li Ruichen Ren Qingyuan Zhao Chengcheng Qi Zhiyu Chen Yang Zhang |
| author_sort | Wenting Li |
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| description | Abstract Background The coronary lumen volume to myocardial mass (V/M) ratio has been suggested as a quantitative metric of potential imbalance between coronary blood supply and myocardial oxygen demand. This study was designed to assess the prognostic value of the V/M ratio for predicting major adverse cardiovascular events (MACE) in patients undergoing transcatheter aortic valve replacement (TAVR). Methods This study enrolled patients who received a standard planning computed tomography (CT) scan before TAVR and dichotomized at the median of 33.31 mm³/g of V/M ratio into groups with low V/M ratio and high V/M ratio. The V/M ratio was calculated by coronary computed tomography angiography (CTA). The endpoint was a composite of all-cause mortality, stroke, and hospitalization for heart failure. The cumulative incidence of the MACE was compared using Kaplan-Meyer plots and uni- and multivariate Cox proportional hazards regression analysis. Results In total, 139 patients were enrolled in this study finally (mean age 71.7 ± 6.7 years, 41.7% female). The mean V/M ratio was considerably lower in patients with MACE than in those without MACE (26.5 ± 4.9mm3/g vs. 34.0 ± 3.8mm3/g, P<0.001). Multivariate Cox proportional hazards regression showed that the low V/M ratio group (≤ 33.31 mm³/g) had a higher risk of MACE after TAVR (HR: 6.14, 95%CI: 1.37–27.54; P = 0.018). Conclusions The lower V/M ratio could serve as an independent predictor of MACE in patients undergoing TAVR. Clinical trial number Not applicable. |
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| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-befd0d71d6bb40bdb6fe53ad2c43c06b2025-08-20T02:30:19ZengBMCBMC Cardiovascular Disorders1471-22612025-04-012511810.1186/s12872-025-04705-9Computed tomography-based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement: a novel method for risk assessmentWenting Li0Ruichen Ren1Qingyuan Zhao2Chengcheng Qi3Zhiyu Chen4Yang Zhang5Department of Radiology, Qilu Hospital of Shandong UniversityDepartment of Radiology, Qilu Hospital of Shandong UniversityDepartment of Radiology, Qilu Hospital of Shandong UniversityDepartment of Radiology, Qilu Hospital of Shandong UniversityDepartment of Radiology, Qilu Hospital of Shandong UniversityDepartment of Radiology, Qilu Hospital of Shandong UniversityAbstract Background The coronary lumen volume to myocardial mass (V/M) ratio has been suggested as a quantitative metric of potential imbalance between coronary blood supply and myocardial oxygen demand. This study was designed to assess the prognostic value of the V/M ratio for predicting major adverse cardiovascular events (MACE) in patients undergoing transcatheter aortic valve replacement (TAVR). Methods This study enrolled patients who received a standard planning computed tomography (CT) scan before TAVR and dichotomized at the median of 33.31 mm³/g of V/M ratio into groups with low V/M ratio and high V/M ratio. The V/M ratio was calculated by coronary computed tomography angiography (CTA). The endpoint was a composite of all-cause mortality, stroke, and hospitalization for heart failure. The cumulative incidence of the MACE was compared using Kaplan-Meyer plots and uni- and multivariate Cox proportional hazards regression analysis. Results In total, 139 patients were enrolled in this study finally (mean age 71.7 ± 6.7 years, 41.7% female). The mean V/M ratio was considerably lower in patients with MACE than in those without MACE (26.5 ± 4.9mm3/g vs. 34.0 ± 3.8mm3/g, P<0.001). Multivariate Cox proportional hazards regression showed that the low V/M ratio group (≤ 33.31 mm³/g) had a higher risk of MACE after TAVR (HR: 6.14, 95%CI: 1.37–27.54; P = 0.018). Conclusions The lower V/M ratio could serve as an independent predictor of MACE in patients undergoing TAVR. Clinical trial number Not applicable.https://doi.org/10.1186/s12872-025-04705-9Coronary computed tomography angiographyTranscatheter aortic valve replacementCoronary lumen volumeLeft ventricle myocardial massVolume to myocardial mass |
| spellingShingle | Wenting Li Ruichen Ren Qingyuan Zhao Chengcheng Qi Zhiyu Chen Yang Zhang Computed tomography-based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement: a novel method for risk assessment BMC Cardiovascular Disorders Coronary computed tomography angiography Transcatheter aortic valve replacement Coronary lumen volume Left ventricle myocardial mass Volume to myocardial mass |
| title | Computed tomography-based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement: a novel method for risk assessment |
| title_full | Computed tomography-based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement: a novel method for risk assessment |
| title_fullStr | Computed tomography-based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement: a novel method for risk assessment |
| title_full_unstemmed | Computed tomography-based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement: a novel method for risk assessment |
| title_short | Computed tomography-based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement: a novel method for risk assessment |
| title_sort | computed tomography based coronary lumen volume to myocardial mass ratio in patients undergoing transcatheter aortic valve replacement a novel method for risk assessment |
| topic | Coronary computed tomography angiography Transcatheter aortic valve replacement Coronary lumen volume Left ventricle myocardial mass Volume to myocardial mass |
| url | https://doi.org/10.1186/s12872-025-04705-9 |
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